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What Is Verapamil Used For

what is verapamil used for

Side Effects of Verapamil 120mg:

Bradycardia, CHF, MI, AV Block, Worsening Heart Failure, Transient Asystole, Hypotension, Pulmonary And Peripheral Oedema, Nausea. Constipation, Fatigue, Hypotension, Dizziness, Headache, Palpitation, Flushing, Nausea, Rashes, Alopecia, Hyperprolactinaemia, Increased LFT And Arthralgia. Potentially Fatal: Heart Block And Cardiac Failure In Patients With Preexisting Cardiac Disease. Hepatotoxicity.

Drug Interactions of Verapamil 120mg:

Increased Cardiac Depressant Effects With Β-Blockers And Flecainide. Increased Risk Of Additive Bradycardia, Conduction Disturbances And Digoxin Toxicity With Digoxin. Increased Risk Of Bradycardia And Hypotension With Remifentanil And Sufentanil. Increased Levels Of Both Everolimus And Verapamil On Concurrent Use.

 May Increase Doxorubicin, Buspirone, Carbamazepine, Ciclosporin, Epirubicin, Eplerenone, Quinidine, Statins, Sirolimus, Tacrolimus, Quinupristin/Dalfopristin Levels. Verapamil Increase Blood Alcohol Levels. Unpredictable Interactions With Lithium.

Decreased Verapamil Concentrations With Phenobarbital, Sulfinpyrazone, Rifampicin, Rifabutin And Rifapentine. Increased Verapamil Concentrations With Protease Inhibitors And Cimetidine. Potentially Fatal: Increased Cardiac Depressant Effects With Amiodarone. Increased Risk Of QT Prolongation With Dofetilide, Ranolazine, Sertindole.

 Additive Bradycardia With Ivabradine. Increased Risk Of Heart Block With Clonidine. Increased Risk Of Acute Hyperkalaemia And CV Collapse With Dantrolene.

Mechanism of Action of Verapamil 120mg:

Verapamil Inhibits Entry Of Calcium Ions Into Arterial Smooth Muscle Cells As Well As The Myocytes And Conducting Tissue. These Actions Lead To Reversal And Preventions Of Coronary Artery Spasm, Reduction In Afterload Through Peripheral Vasodilatation And Reduction In Ventricular Rate In Patients With Chronic Atrial Flutter Or Fibrillation And Reduction In The Occurrence Of Paroxysmal Supraventricular Tachycardia. Verapamil Reduces BP, Relieves Angina And Slows AV Conduction. Onset: 5 Min (IV); 1-2 Hr (Oral). Duration: Absorption: 90% Absorbed From GI Tract. Bioavailability: 20% (Due To Extensive First-Pass Metabolism).

 Peak Plasma Concentration: 1-2 Hr. Distribution: Protein-Binding: 90%. Crosses Placenta And Distributed Into Breast Milk. Metabolism: Extensively Metabolised In Liver To >12 Metabolites. Terminal Half-Life: 2-8 Hr (After Single Dose); Increased To 4.5-12 Hr (After Repeated Doses). Excretion: Excreted By Kidney (70% Of Dose) As Metabolites And Via Bile Into Faeces (16%). <4% Excreted Unchanged.

Special Precautions for Verapamil 120mg:

1st Degree AV Block. Hypertrophic Cardiomyopathy, Patients With Decreased Neuromuscular Transmission. Bradycardia Or Conduction Disturbances. Hepatic Or Renal Impairment. For IV Admin, Verapamil To Be Given Slowly Under Continuous ECG And BP Monitoring.

Conventional Tablets, Extended-Release Capsules, Extended-Release Core Tablets, And Controlled Extended-Release Capsules Can Be Admin Without Regard To Food While Extended-Release Tablets To Be Admin With Food. Slower Infusion Rates (Over >3 Min) In Elderly. Periodic Monitoring Of LFT During Long-Term Therapy. Avoid Sudden Withdrawal. Infants And Neonates, Elderly. Pregnancy And Lactation.

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