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What Is Memantine Hcl Used For

what is memantine hcl used for


Oral N-methyl-D-aspartate (NMDA) receptor antagonist

For use in moderate to severe Alzheimer's disease both as monotherapy and in combination with donepezil

Concurrent medical conditions, drugs, or foods that raise urine pH may decrease urinary elimination of memantine and increase exposure, potentially increasing the risk of adverse effects


Before taking this product, tell your doctor or pharmacist if you are allergic to memantine; or to donepezil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, severe urinary tract infections, recent dietary change (from a high-protein diet to a vegetarian diet), stomach/intestinal disease (such as bleeding, ulcers), difficulty urinating (such as due to enlarged prostate), seizures, breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD).

Donepezil may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using this product, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Side Effects

Diarrhea, nausea, vomiting, loss of appetite, increased weight, loss of bladder control, back pain, headache, bruising, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of stomach/intestinal bleeding (such as black/bloody stools, vomit that contains blood or looks like coffee grounds, stomach/abdominal pain), difficulty urinating, mental/mood changes (such as depression, aggression).

Get medical help right away if you have any very serious side effects, including: fast/slow/irregular heartbeat, severe dizziness, fainting, seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Dosage & Indications

Oral dosage (immediate-release tablets or oral solution)

Initially, 5 mg PO once daily. Then, titrate slowly over 3 weeks. Increase the dose by 5 mg/week over a 3-week period to a target dose of 10 mg PO twice daily at week 4. Periodic evaluation may be helpful to determine treatment duration (i.e., continue treatment if improvement or stability in functional, cognitive or behavioral status continues).

Oral dosage (extended-release capsules)

Initially, 7 mg PO once daily. Titrate in 7-mg increments at no sooner than 1 week intervals up to the recommended target dose of 28 mg PO once daily. During titration , ensure that the previously established dose is well-tolerated before increasing to the next dosage level. Max: 28 mg/day PO. conversion from immediate-release (IR): Convert 10 mg twice daily of the IR forms to 28 mg PO once daily of the ER capsules, beginning the day after the last dose of the IR dose form. There are no data on the comparative efficacy of these 2 regimens.

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