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What Is Glimepiride

What Is Glimepiride

What Is Glimepiride

Glimepiride is a prescription drug. It comes as an oral tablet.

Glimepiride is available as the brand-name drug Amaryl and as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Use

Glimepiride is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Glimepiride belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin.

How it works

Glimepiride belongs to a class of drugs called sulfonylureas. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Glimepiride helps your pancreas to release insulin. Insulin is a chemical that your body makes to move sugar (glucose) from your bloodstream into your cells. Once the sugar enters your cells, they can use it as fuel for your body.

With type 2 diabetes, your body doesn’t make enough insulin, or it can't properly use the insulin that it makes, so the sugar stays in your bloodstream. This causes high blood sugar levels (hyperglycemia).

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • severe low blood sugar (less than 35 to 40 mg/dL). Symptoms may include:
  • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
  • confusion, including delirium
  • lightheadedness or dizziness
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue
  • lack of coordination
  • nightmares or crying out in your sleep
  • seizures
  • unconsciousness

Dosage

Missed Dose

The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

Overdose

It is recommended to discontinue the medication and contact your doctor immediately if an overdose is suspected. Symptoms like dizziness, confusion, increased heartbeat, tremor and sweating after taking the medication should be reported immediately.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Liver/Kidney disease

Glimepiride should be administered with caution in patients with a disorder of kidney and/or liver. Suitable dosage adjustments and monitoring of blood sugar levels are necessary in such cases.

Allergy

This medicine is not recommended for use in patients with known history of allergy to Glimepiride or other drugs belonging to the Sulphonamide class of antidiabetic medicines.

Fluid Retention

 Glimepiride can cause retention of fluid in some cases that may lead to severe and harmful effects on the body.

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