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What Is Apixaban Used For

What Is Apixaban Used For

Uses

Apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming, which can travel to other parts of your body (such as the lungs or legs) or increase your risk for stroke. In the United States, apixaban is also approved to treat certain types of blood clots (deep vein thrombosis-DVT, pulmonary embolus-PE) and to prevent them from forming again.

Apixaban is an anticoagulant that works by blocking certain clotting proteins in your blood.

Why it’s used

Apixaban is used to:

lower your risk of blood clots and stroke if you have atrial fibrillation without an artificial heart valve

prevent deep vein thrombosis (blood clot in your legs) or pulmonary embolism (blood clot in your lungs) after hip or knee replacement surgery

prevent another occurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE) in people with a history or DVT or PE

treat DVT or PE

How to use Apixaban Tablet

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking apixaban and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice daily (every 12 hours). If you cannot swallow the tablet whole, you may crush the tablet and mix with water, apple juice, or applesauce and take it right away.

Precautions

Before taking apixaban, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), blood disorders (such as anemia, hemophilia, thrombocytopenia), recent major injury/surgery, stroke, frequent falls/injuries.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin, enoxaparin), certain antidepressants (including SSRIs such as fluoxetine, SNRIs such as desvenlafaxine/venlafaxine).

What are the side effects of apixaban?

The most common side effects of apixaban involves bleeding in the:

  • stomach,
  • intestines,
  • brain, and
  • eyes.
  • Easy bruising
  • Unusual bleeding or bleeding that won't stop, including nosebleeds and bleeding gums
  • Heavy menstrual periods
  • Pink, brown, or red urine
  • Black or bloody stools
  • Coughing up blood, or vomit that looks like coffee grounds
  • Trouble breathing or wheezing
  • Severe headache
  • Dizziness or feeling like you might pass out
  • Severe weakness
  • Rash
  • Swelling or joint pain
  • Chest pain or tightness

What is the dosage for apixaban?

The usual dose in nonvalvular atrial fibrillation is 5 mg by mouth twice daily. For individuals 80 years or older, weighing less than or equal to 60 kg, or with reduced kidney function, the usual dose is 2.5 mg twice daily.

The recommended dose for treating DVT or pulmonary embolism is 10 mg twice daily for the first 7 days and then 5 mg twice daily. After six months of treatment, the dose may be reduced to 2.5 mg daily for prevention of DVT or pulmonary embolism.

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