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Viagra Sildenafil

viagra sildenafil

History of sildenafil as Viagra

Sildenafil citrate was created in 1989 by British scientists Albert Wood and Peter Dunn as a possible treatment for hypertension and angina; conditions associated with coronary heart disease. In 1991 Dr. Nicholas Terrett, now often referred to as the father of Viagra, was named in the British patent for the drug as a heart medication. And though Pfizer’s early trials of the drug in the 1990s did not prove its efficacy as a heart medication, patients who took part in the clinical trials reported increased erections after taking sildenafil. Separate studies provided more information on the biochemical process that causes erections, which helped scientists understand how sildenafil could enhance the effects of sexual stimulation and open up blood vessels in the penis. Sildenafil was then studied in men with erectile dysfunction, and in 1998 it was approved by the FDA specifically for treatment of ED.

Sildenafil (generic Viagra) becomes available

When Pfizer lost its UK patent for the drug in June 2013 it made way for generic manufacturers to produce sildenafil, or ‘generic Viagra’. It costs a fraction of the price of Viagra, and has made the treatment more accessible to a wider range of patients. You can now choose to buy Viagra, Pfizer’s branded drug, or sildenafil, the generic version.

How are Viagra Connect, Viagra, and Sildenafil related?

They are the same from a medical point of view – Viagra Connect, Viagra and Sildenafil are all related because they contain the same active ingredient, sildenafil citrate. As a result they all have the exact same effect during treatment. The only difference is branding:Sildenafil is a generic medicine and produced by several manufacturers Viagra, is the branded version of Sildenafil patented by the company, PfizerViagra Connect is 'over-the-counter Viagra', which is also made by PfizerSildenafil was invented first, by accident – sildenafil citrate (the active ingredient in all 3 medications) was discovered as a treatment for ED by accident. The researchers who discovered it were originally testing new treatments for high blood pressure (hypertension). Sildenafil, however, didn’t relieve the symptoms of hypertension properly. Instead 80% of 4000 male participants found they got an erection more easily when they took sildenafil. Therefore, the drug was subjected to testing and was later approved by the Food and Drug Administration (FDA) for the treatment of ED.The patent for sildenafil medication was created by Pfizer – Viagra was born from the discovery of sildenafil as an ED treatment. Although they are both the same, Viagra is the brand name for the sildenafil produced and sold by the company, Pfizer. This was until the patent expired and Sildenafil could be sold as a cheaper generic medication.

Effects

Viagra can help men who cannot achieve or sustain an erection due to erectile dysfunction. It improves the erectile response when a man is already sexually stimulated, but it does not provide sexual stimulation. If there is no sexual stimulation, viagra will not work.When sexual stimulation occurs, nitric oxide is released by the nervous system in the erectile tissue of the penis. Nitric oxide stimulates an enzyme that produces messenger cyclic guanosine monophosphate (cGMP).cGMP causes the arteries in the penis to dilate, so that the arteries and the erectile tissue fill with blood. An erection results.Viagra prevents cGMP from becoming degraded, so the blood flow and the erection can continue.

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