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Verapamil Cream

verapamil cream


Topical Verapamil is a compounded medication that is designed to treat most myo-fibrotic conditions. Through studies, both placebo controlled and subjective, it has been shown that Verapamil is an effective first line treatment for multiple conditions including, Peyronie’s Disease, Dupuytren’s Contracture and Ledderhose Disease (plantar faciitis). Please note that Topical Verapamil has not, as yet, been FDA approved for the treatment of these conditions but is considered an off-label prescription.

Verapamil is a drug that belongs to a group or class of drug referred to as calcium channel blockers. Originally designed for high blood pressure it has been determined that the mechanism of action of verapamil, used topically, initiates a reaction that results in a lessening or softening of collagen.

Collagen or scar tissue is usually due to trauma to a specific area in other cases it is due to a genetic predisposition, such as with keloids, Dupuytren’s contracture and Peyronie’s disease. Topical Verapamil has the ability to reduce the size, elasticity and other negative qualities associated with the overproduction of collagen. This is accomplished by getting the drug through the skin with a delivery agent and causing the production of an enzyme which reverses some of the effects of the collagen.

How Does Topical Verapamil Peyronie's Treatment Work?

PDLabs holds the patent to Transdermal Verapamil 15% Gel, but there are generics available. It is only available as prescription from your doctor.

It is not entirely understood how Transdermal Verapamil 15% Gel works on Peyronie's disease. However, it appears that the Verapamil gel penetrates into the plaque or scar tissue, blocks calcium from entering the tissue, and causes the body to produce an enzyme, collagenase, that may remodel the plaque.

What About Corticosteroid Injections?

Although there are no major studies looking at the use of corticosteroid injections for plantar fibromatosis, numerous authors mention the treatment modality in their papers as a viable conservative treatment option.

 Pentland and Anderson described a patient with bilateral multi-nodular plantar fibromas.4 The patient received five intralesional injections of 15 mg to 30 mg of triamcinolone acetonide in each nodule. The authors used triamcinolone 40 mg/cc diluted 3:1 with 1% lidocaine for a final concentration of 30 mg/cc. They injected each nodule with 0.5 cc to 1.0 cc. Each injection occurred a month apart.They noted softening of the nodules during their injection course. Four months after their last injection, they noted the nodules were smaller.

Before taking this medicine

You should not use verapamil if you are allergic to it, or if you have a serious heart condition such as:

  • "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
  • severe heart failure;
  • slow heartbeats that have caused you to faint; or
  • certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart).
  • To make sure verapamil is safe for you, tell your doctor if you have:
  • congestive heart failure;
  • low blood pressure;
  • kidney disease;
  • liver disease; or
  • a nerve-muscle disorder such as myasthenia gravis or muscular dystrophy.
  • It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
  • Verapamil can pass into breast milk and may cause side effects in the nursing baby. You should not breast-feed while using this medicine.

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