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Use Of Voriconazole

Use Of Voriconazole

How should I use this medication?

The recommended adult starting dose of voriconazole is either 200 mg or 400 mg, taken 12 hours apart for the first 24 hours. After the first 24 hours, the recommended dose is 100 mg or 200 mg, taken twice daily.  For both the starting dose and the maintenance dose, the dose used depends on your body weight and the type of infection. Your dose may be adjusted by your doctor depending on how you respond to voriconazole and the side effects you experience.

Injection: The dose for voriconazole intravenous (into the vein) injection depends on body weight and the type of infection. Your doctor will determine the right dose for you. The typical recommended starting dose of voriconazole injection during the first 24 hours is 2 doses of 6 mg for each kilogram of body weight, given 12 hours apart. After the first 24 hours, the recommended dose is 3 mg or 4 mg for each kilogram of body weight twice daily.

If you are using the oral suspension, shake the closed bottle for approximately 10 seconds before each use. The suspension should only be administered using the oral dispenser supplied with each pack.

Voriconazole oral suspension should not be mixed with any other medication or flavouring agent and it should not be further diluted with water or any other drinks.

Dosage

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine. Voriconazole will not treat a viral infection such as the flu or a common cold.Voriconazole is sometimes given for up to several days after lab tests show that the infection has cleared. Very severe infections may need to be treated for several weeks.While using voriconazole, you may need frequent blood tests. Your vision and kidney or liver function may also need to be checked.

Side Effects

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have chest tightness or trouble breathing.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • a sunburn;
  • vision problems, changes in your color vision;
  • slow heart rate, weak pulse, fainting, slow breathing;
  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
  • liver problems--nausea, vomiting, flu-like symptoms, itching, feeling very tired, or jaundice (yellowing of the skin or eyes); or
  • severe skin reaction--fever, mouth sores, swelling in your face or tongue, trouble breathing or swallowing, rash with blistering and peeling.

Storage

  • Keep your tablets in the pack until it is time to use them.
  • If you take the tablets out of the blister pack they may not keep well.
  • Keep your tablets in a cool dry place where the temperature stays below 30°C.

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