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Tropicamide + Phenylephren

Tropicamide+Phenylephren

Description

Phenylephrine 2.5% eyedrops are safe for routine clinical use, according to a systematic review and metaanalysis. Blood pressure (BP) and heart rate (HR) change after administration of phenylephrine 10%, but the changes are short-lived and of uncertain clinical significance.

Indications

It is used as a mydriatic remedy:

  • For diagnostic ophthalmic procedures.
  • Prior to surgical and laser operations.

Dosage and Administration

For dilation of the pupil for ophthalmic diagnostic and surgical interventions in the conjunctival sac instill 1-2 drops at15-30 minutes before the procedure or surgery.

Over-Dosage

Symptoms (in case of accidental oral administration): dryness of the skin and mucous membranes, hyperthermia, tachycardia, mydriasis, agitation, convulsions, coma, respiratory depression.

Warning and Precautions

Due to changes in accommodation and pupil width after using the drug visual acuity is possibly reduces, and the use of the drug is not recommended when driving a vehicle and during the occupation of other potentially hazardous activities that require high concentration and quickness of psychomotor reactions.Due to a significant reduction in the pupil dilator in 30-45 min after instillation particles of pigment from the pigment layer of the iris can be detected in the anterior chamber moisture. A suspension of moisture in the chamber must be differentiated with manifestations of anterior uveitis or a hit of blood cells in the anterior chamber of the moisture. Preservatives contained in the product may be absorbed by soft contact lenses. The drug can be irritating to the eyes when wearing contact lenses, so any contact lenses should be removed before instillation and put on no earlier than 15 minutes after it.

To reduce the risk of systemic side effects it is recommended to slight press with the finger on the projection area of the lacrimal sac at the inner corner of eye for 1-2 minutes after instillation.

Side Effects

Topical:

Allergic reactions, increased intraocular pressure, transient pain, burning sensation in the eye and photophobia, transient decrease in vision, allergic reactions, release of pigment in the aqueous humor with a temporary increase in intraocular pressure, blocking the anterior chamber angle (while narrowing of the angle), pain in the brow, lacrimation, conjunctival hyperemia, keratitis, rarely – reactive miosis on the day after application (repeat instillation of the drug at this time may give a less pronounced mydriasis than the day before, the effect is often seen in elderly patients).

System:

Pale skin, dry mouth, flushed dry skin, contact dermatitis, headache, bradycardia, tachycardia and arrhythmia, high blood pressure, ventricular occlusion of the coronary arteries, pulmonary embolism, disorders of the central nervous system and muscular rigidity, frequent urge to urinate , difficulty urinating, decreased tone of the gastro-intestinal tract motility, leading to constipation. Sometimes – vomiting and dizziness.In elderly patients with diseases of the cardiovascular system may be ventricular arrhythmia, myocardial infarction.

Storage Conditions

  • Store at temperatures below 25 °C in a dark place
  • Do not freeze. Keep out of reach of children.
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