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Trimetazidine is a drug for angina pectoris sold under the brand name Vastarel MR. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart, which leads to an exacerbation of ischemic injury and decreased cardiac efficiency during reperfusion.

Uses of Trimetazidine

Angina pectoris

This medicine is used in the treatment of stable angina pectoris, chest pain caused by diminished oxygen supply to the myocardium.

Side effects

  • Major & minor side effects for Trimetazidine
  • HypersensitivitySEVERERARE
  • Headache
  • Nausea and vomitingSEVERE
  • Abdominal pain
  • Fatigue

Are there any missed dose instructions?

If you miss a dose of Trimetazidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

When not to use?

Contraindications of Trimetazidine

Allergy:This medicine is not recommended for use in patients with a known allergy to trimetazidine or any other components present along with it.

Parkinson's disease:This medicine is not recommended for use in patients with Parkinson's disease since it may worsen the symptoms of Parkinson's.

Severe renal impairment:Trimetazidine is not recommended for use in patients with severe renal impairment (CrCl less than 30 ml/minute) due to the increased risk of worsening of the patient's condition.