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Topiramate Phentermine

Topiramate Phentermine

What is phentermine and topiramate?

Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is a seizure medication, also called an anticonvulsant.The combination of phentermine and topiramate is used together with diet and exercise to treat obesity. This medication is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.emtPhentermine and topiramate will not treat any underlying condition you have (such as heart disease, diabetes, high blood pressure). Keep taking any other medications your doctor has prescribed to treat these conditions.Phentermine and topiramate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking phentermine and topiramate?

donotDo not use this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.donot               You should not take this medication if you are allergic to phentermine (Adipex-P, Oby-Cap, Suprenza, T-Diet, Zantryl) or topiramate (Topamax), or if you have:To make sure you can safely take phentermine and topiramate, tell your doctor if you have any of these other conditions:high blood pressure, heart disease (coronary artery disease, heart rhythm problems, congestive heart failure, pulmonary hypertension);

  • diabetes;
  • liver or kidney disease;
  • low levels of potassium in your blood; or
  • if you have had a heart attack or stroke in the past 6 months.

Dosage Forms & Strengths

phentermine/topiramate (combination of immediate-release phentermine and extended-release topiramate)

  • 3.75mg/23mg
  • 7.5mg/46mg
  • 11.25mg/69mg
  • 15mg/92mg


Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to any other sympathomimetic amines (including decongestants such as pseudoephedrine, stimulants such as amphetamine, appetite suppressants such as diethylpropion); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, glaucoma, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), heart disease.

Side Effects

  • mood changes such as depression,
  • trouble sleeping (insomnia),
  • confusion,
  • dizziness,
  • anxiety,
  • tiredness,
  • irritability,
  • constipation,
  • numbness or tingly feeling,
  • altered sense of taste,
  • dry mouth,
  • unpleasant taste in your mouth,
  • headache,
  • upper respiratory tract infection,
  • runny or stuffy nose,
  • sinus infection,
  • back pain,
  • flu symptoms,
  • bronchitis,
  • fatigue,
  • nausea,
  • diarrhea,
  • cough,
  • urinary tract infection,
  • blurred vision,
  • pain in extremities,
  • depression,
  • rash,
  • stomach pain or upset,
  • muscle spasms,
  • indigestion,
  • thirst,
  • eye pain,
  • dry eyes,
  • palpitations,
  • hair loss,
  • loss of appetite,
  • changes in menstrual periods,
  • muscle pain,
  • neck pain.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

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