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Topiramate For Pain

Topiramate For Pain

Description

This study will test the effectiveness of topiramate to treat pain caused by lumbar radiculopathy, or sciatica. Sciatica results from damage to the lumbar nerve roots, typically causing back pain and sharp, shooting pain down one or both legs. Although sciatica is common, there are no good treatments for it. Topiramate belongs to a group of medications commonly used to treat pain caused by nerve damage.Patients between 18 and 75 years of age who have had sciatica pain daily for at least 3 months may be eligible for this study. (This is taken from the first paragraph of the Qualification Criteria in the consent form. The inclusion criteria on page 6 of the protocol say "low back pain of 3 months duration or longer present at least 5 out of 7 days a week" and signs and symptoms of lumbar radiculopathy. Which is correct?)

Side effects

  • nervousness
  • upper respiratory tract infection
  • speech problems
  • tiredness
  • dizziness
  • slowed reactions
  • trouble with memory
  • abdominal pain
  • fever
  • numbness or tingly feeling in the hands or feet,
  • coordination problems,
  • diarrhea,
  • weight loss,
  • speech/language problems,
  • changes in vision,
  • sensory distortion,
  • loss of appetite,
  • bad taste in your mouth,
  • confusion,
  • slowed thinking,
  • trouble concentrating or paying attention,
  • memory problems,
  • and cold symptoms

Precautions

Before taking topiramate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain eye problem (narrow angle glaucoma), kidney problems (such as kidney stones), liver problems, mental/mood problems (such as depression, thoughts of suicide), lung/breathing problems, a certain metabolic imbalance (metabolic acidosis), long-term diarrhea, a diet high in fat and low in carbohydrates (ketogenic diet), brittle bones (osteoporosis).

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, loss of consciousness.

Laboratory and/or medical tests (such as eye exams, bicarbonate blood level) should be performed to monitor your progress and check for side effects.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is within 6 hours of your next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up. If you miss more than one dose, call your doctor for advice.

Storage

Store in a tightly closed container at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised July 2018. Copyright(c) 2018 First Databank.

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