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Topiramate For Migraines Dosage

Topiramate For Migraines Dosage

Description

Topiramate is indicated for the prevention of migraine in adults. It is taken by mouth as preventive therapy to reduce migraine frequency. For those with frequent migraine attacks, or migraine that do not respond to acute treatment, preventive medications can be important.

How does Topiramate work?

The precise way topiramate for migraines dosage works to prevent migraine is unknown. It is thought that the medication blocks sodium channels and increases the activity of neurotransmitters in the brain. This likely inhibits some of the receptors in nerve cells, which reduce electrical activity and contribute to the development of migraine.

What are the brand names for Topiramate?

Topiramate is a generic drug sold under several different brand names in the US and Canada:

  • Topamax
  • Trokendi XR
  • Topiragen
  • Qudexy XR

What are the possible side effects of Topiramate?

 Many clinical trials evaluated the safety and efficacy of Topiramate. The most common side effects experienced by those taking Topiramate include:

  • Decreased sweating
  • Fever and flushing
  • Vision problems
  • Metabolic acidosis (increased level of acid in your blood)
  • Numbness or tingling in the fingers and toes (paresthesia)
  • Anorexia
  • Weight loss
  • Diarrhea
  • Nausea
  • Feeling weak, drowsy, or tired
  • Upper respiratory infections
  • Speech and memory difficulties

Dosing

in patients 2 to 9 years of age is based on weight. During the titration period, the initial dose of TOPAMAXis 25 mg/day nightly for the first week. Based upon tolerability, the dosage can be increased to 50 mg/day (25 mg twice daily) in the second week. Dosage can be increased by 25–50 mg/day each subsequent week as tolerated. Titration to the minimum maintenance dose should be attempted over 5–7 weeks of the total titration period. Based upon tolerability and clinical response, additional titration to a higher dose (up to the maximum maintenance dose) can be attempted at 25–50 mg/day weekly increments. The total daily dose should not exceed the maximum maintenance dose for each range of body weight

How is topiramate for migraines dosage?

Topamax is available in 25mg, 50mg, 100mg, and 200mg tablets. It's also available in 15mg and 25mg capsules. Topamax is commonly dosed by safely tapering up the dose to a therapeutic level, which is 100mg or 200mg daily. For example, a neurologist may start a patient at 25mg once daily for a week and then increase the dose by 25mg every week, until the person is taking 100mg or 200mg daily. This minimizes side effects while maximizing the medication benefit.Likewise, if a person is stopping Topamax, tapering the dose down is also recommended.

What are the Potential Side Effects of Topamax?

One serious side effect of Topamax is a syndrome of acute myopia associated with secondary angle closure glaucoma. Symptoms include a sudden onset of vision and/or eyeball pain. These symptoms, if they occur, usually start within one month of starting Topamax, and can occur in children, as well as in adults. Treatment of this eye syndrome is to stop Topamax as quickly as possible, with the judgment and monitoring of the doctor who prescribed it.Another serious side effect is the elevation of a person's body temperature due to decreased sweating. This is more common in children taking Topamax.

Drug Interactions

Before starting Topamax, be sure to give your physician a list of all the drugs you are using, including prescription, over-the-counter (OTC), vitamins, herbal supplements, and recreational drugs.Using carbamazepine (Tegretol) or phenytoin (Dilantin) may increase the elimination of Topamax from your body, making it less effective.

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