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Tigecycline is an antibiotic for a number of bacterial infections. It is a glycylcycline administered intravenously. It was developed in response to the growing rate of antibiotic resistant bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E.

What is Tigecycline?

Tygacil (tigecycline) is an antibiotic that fights bacteria in the body.

Tygacil is used to treat many different bacterial infections of the skin or the digestive system, as well as pneumonia.

Tygacil should be used only for infections that cannot be treated with other medicines.

taking this medicine

You should not use Tygacil if you are allergic to tigecycline.

To make sure Tygacil is safe for you, tell your doctor if:

you have liver disease;

you are using a blood thinner (warfarin, Coumadin, Jantoven); or

you are allergic to a tetracycline antibiotic (demeclocycline, doxycycline, minocycline, tetracycline).

How is Tigecycline given?

Tygacil is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Tygacil is usually given once every 12 hours. Follow your doctor's dosing instructions very carefully. The medicine must be given slowly, and each IV infusion can take 30 to 60 minutes to complete.

dosing information

Approved indication: For the treatment of complicated intraabdominal infections due to susceptible isolates of Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus anginosus group (includes S anginosus, S intermedius, and S constellatus), Bacteroides fragilis, B thetaiotaomicron, B uniformis, B vulgatus, Clostridium perfringens, and Peptostreptococcus micros.

Side Effects

  • nausea,
  • vomiting,
  • headache,
  • dizziness,
  • sleep problems (insomnia),
  • pain or swelling at the injection site, or
  • vaginal itching or discharge.

 Tell your doctor if you have serious side effects of Tygacil including:

  • sunburn (sun sensitivity),
  • changes in the amount of urine,
  • unusual fatigue,
  • severe stomach or abdominal pain,
  • hearing changes (e.g., ringing in the ears, decreased hearing),
  • irregular heartbeat,
  • easy bleeding or bruising,
  • yellowing of the eyes or skin, or
  • dark urine.



If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

 This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

 If you are using this medication for a longer time, lab and/or medical tests (such as liver function tests, blood counts, cultures) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.


Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

 Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised May 2018. Copyright(c) 2018 First Databank, Inc.