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Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias.


This medication is used to treat certain mental/mood disorders (e.g., schizophrenia). This medication helps you to think more clearly, feel less nervous, and take part in everyday life. It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others. It can help decrease your negative thoughts and hallucinations. Thioridazine belongs to a class of drugs known as phenothiazines.

How to use Thioridazine

Take this medication by mouth with or without food, usually 2-4 times a day or as directed by your doctor.

Dosage is based on your medical condition and response to therapy. Once your condition improves and you are better for a while, your doctor may work with you to reduce your regular dose. This may be done over time. Do not stop your medication or lower your dose without talking with your doctor first. Some conditions may become worse when the drug is stopped abruptly. Your dose may need to be gradually reduced.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Inform your doctor if your condition persists or worsens.

Side Effects

  • dizziness,
  • drowsiness,
  • difficulty urinating,
  • restlessness,
  • headache,
  • blurred vision,
  • dry mouth,
  • stuffy nose,
  • vomiting,
  • constipation,
  • diarrhea,
  • breast swelling or discharge,
  • changes in your menstrual periods,
  • weight gain,
  • swelling in your hands or feet,
  • impotence,
  • trouble having an orgasm,
  • increased or decreased interest in sex, or
  • itching or skin rash.


Discontinue if QTc interval >500msec occurs. Obtain ECG and K+ levels at baseline, then periodically (esp. after changing dose). Evaluate cardiac function if syncope, dizziness, palpitations, or other symptoms of torsade de pointes occurs. Bradycardia. Hypokalemia (correct K+ before starting). History of breast cancer. Seizure disorders. Monitor blood, liver and visual function. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers.


Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.


Seek emergency medical treatment or contact the doctor in case of an overdose.


All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Description - Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Instructions - Consumption of alcohol is not recommended with this medicine due to an increase in the risk of dizziness, seizures, and irregular heartbeats. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine.