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Tetracycline + Hydrocortisone

Tetracycline + Hydrocortisone

Tetracycline + Hydrocortisone

A randomized, single-blind, controlled study comparing the efficacy of an ointment containing two antibiotics, one containing one antibiotic plus hydrocortisone, and no treatment in reducing secondary infections in patients with patent Guinea worm was undertaken in the northern region of Ghana. Seventy-seven patients were included. Time to complete healing was significantly shorter in the treatment groups compared with the controls (P = 0.044 and P = 0.003, respectively). Secondary infections occurred more often in the controls (P = 0.00014). Ointments containing antibiotics are recommended for application at the early stage of patent Guinea worm infection.

When to use

Chronic and acute adrenocortical insufficiency, and supplement in adrenal insufficiency during surgery under general anesthesia, soft-tissue inflammation, corticosteroid-responsive dermatoses and mucositis, arthritis

How to use

Adrenocortical insufficiency Intravenous (IV): 20-30 mg/day in 2 divided doses. Acute adrenocortical insufficiency 100-500 mg 3-4 times/24 hour depending on severity and response. Corticosteroid-responsive dermatoses Topical: As 0.1-2.5% ointment/cream/lotion, apply as directed. Joint inflammation Intra-articular injection: As acetate, 5-50 mg depending on size of affected joint.


According to the dosage forms the following routes of administration are available:

• Oral

• Parenteral

• Topical

Side Effects

  • Headache, dizziness, intracranial hypertension
  • Aggravates renal & hepatic impairment
  • Nausea
  • Vomiting
  • Epigastric distress
  • Super infection
  • Skin rashes
  • Arrhythmia, Cardiac arrest
  • Neutropenia, Thrombocytopenia
  • Elevated liver enzymes
  • Discoloration of teeth & Retardation of bone growth
  • Esophageal ulceration


Report to the physician if the patients are allergic to the active ingredients and any other drugs & inform about pre-existing diseases and current health conditions.

After long term use of this medicine if any problem occurs please tell the doctor.


Interactions with Tetracycline / Hydrocortisone

If you use other drugs or over the counter products at the same time, the effects of Tetracycline / Hydrocortisone may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Tetracycline / Hydrocortisone may interact with the following drugs and products:

  • Alginic acid
  • Aluminium hydroxide and oxide
  • Aminoglutethimide
  • Amobarbital
  • Amoxicillin
  • Amphotericin B
  • Ampicillin
  • Ascorbic acid
  • Aspirin
  • Atracurium

 Medicines not to use with Tetracycline / Hydrocortisone

Hypersensitivity to Tetracycline / Hydrocortisone is a contraindication. In addition, Tetracycline / Hydrocortisone should not be used if you have the following conditions:

  • Allergic reactions
  • Breastfeeding
  • Children below the age of 5 years
  • Children below the age of eight years
  • Epilepsy
  • Hypersensitivity
  • Lactation
  • New born babies
  • Osteoporosis
  • Peptic ulcer

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.