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Tenofovir Renal Failure

Tenofovir Renal Failure

Description

Research shows that HIV patients who have clinically decreased kidney function are less likely to be prescribed ART, probably because physicians and other healthcare providers are concerned that many of these medications are cleared by the kidneys and don't want to cause further harm,” Dr. Lucas said in the release. “But the outlook for HIV patients with kidney disease is much better now that we have numerous effective treatments for HIV, many of which are not cleared by the kidneys.

Uses

In patients with renal impairment, TDF should only be used if the potential benefits of treatment outweigh the potential risks, and close monitoring of renal function is recommended.TDF is principally eliminated via the kidney and exposure to tenofovir increases in patients with renal dysfunction. Limited data from clinical studies support once daily dosing of TDF in patients with mild renal impairment (creatinine clearance 50–80 mL/min).Administration of Viread 33mg/g granules to provide a reduced daily dose of TDF is recommended in adult patients with creatinine clearance <50 mL/min, including haemodialysis patients,as shown in Table 2. For patients unable to take Viread 33 mg/g granules, prolonged dosageintervals using Viread 245 mg film-coated tablets may be used

Dosages

Dosage Forms & Strengths

tenofovir disoproxil fumarate (ie, tenofovir DF)

tablet

  • 150mg
  • 200mg
  • 250mg
  • 300mg
  • powder, oral
  • 40mg/g of powder (ie, 1 scoopful)

Side Effect

Dizziness, diarrhea, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, anxiety, confusion), signs of kidney problems (such as a change in the amount of urine), unusual thirst, muscle cramps/weakness.

Precaution

  • Should not be coadministered with combination antiretroviral agents containing tenofovir
  • Immune reconstitution syndrome may occur if used in combination with other antiretroviral drugs
  • Risk of lactic acidosis and severe hepatomegaly with all NRTIs
  • Additive toxicity when coadministered with adefovir
  • Acute exacerbations of hepatitis in patients with HBV if drug is stopped
  • May cause redistribution/accumulation of body fat that may result in cushingoid appearance

How should tenofovir disoproxil fumarate be stored?

Store tenofovir DF at room temperature, 68°F to 77°F (20°C to 25°C). Keep tenofovir DF in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.Do not use tenofovir DF if the original seal over the container opening is broken or missing.

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