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Tenofovir Disoproxil Fumarate Emtricitabine

Tenofovir Disoproxil Fumarate Emtricitabine

What are the most important things to know about tenofovir disoproxil fumarate emtricitabine?

tenofovir disoproxil fumarate emtricitabine can cause serious, life-threatening side effects. These include a buildup of lactic acid in the blood (lactic acidosis) and liver problems.

  • Weakness or tiredness
  • Unusual (not normal) muscle pain
  • Shortness of breath or fast breathing
  • Stomach pain with nausea and vomiting
  • Hands or feet that feel cold or turn blue
  • Dizziness or lightheadedness
  • Fast or irregular heartbeat

What should I do if I forget a dose?

If you miss a dose of tenofovir disoproxil fumarate emtricitabine, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take more than one dose of Truvada in a day. Do not take two doses at the same time to make up for a missed dose.

side effects

Truvada may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.

  • dizziness,
  • trouble sleeping,
  • drowsiness,
  • unusual dreams, and
  • trouble concentrating.
  • tiredness,
  • headache,
  • nausea,
  • vomiting,
  • gas,
  • upset stomach,
  • diarrhea, and
  • skin discoloration (such as small spots/freckles, darkening of the palms of the hands/soles of the feet), and
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).


Before taking emtricitabine/tenofovir, tell your doctor or pharmacist if you are allergic to either of the medications; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

What other drugs will affect tenofovir disoproxil fumarate emtricitabine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Emtricitabine and tenofovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).


All patients should be tested for the presence of chronic hepatitis B virus (HBV) before or when initiating

Before initiating and during use, on a clinically appropriate schedule, assess serum creatinine, estimated creatinine clearance, urine glucose and urine protein in all patients; in patients with chronic kidney disease, also assess serum phosphorus

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