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Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate

What is tenofovir disoproxil fumarate?

Tenofovir disoproxil fumarate (tenofovir DF) is a type of anti-HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI). The prescription medicine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older. Tenofovir DF is always used in combination with other anti-HIV medicines.

Tenofovir DF is also a hepatitis B virus (HBV) reverse transcriptase inhibitor, approved by the FDA for the treatment of chronic HBV infection in adults. HBV is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

Tenofovir side effects

  • depression
  • pain
  • back pain
  • diarrhea
  • headache
  • trouble sleeping
  • nausea or vomiting
  • rash


Tenofovir is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Tenofovir belongs to a class of drugs known as nucleotide reverse transcriptase inhibitors (NRTIs).

How it works

Tenofovir belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). It’s also a hepatitis B virus reverse transcriptase inhibitor (RTI). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Tenofovir works in the same way for both HIV infection and chronic hepatitis B virus infections. It blocks the effectiveness of reverse transcriptase, an enzyme required for each virus to make copies of itself. Blocking reverse transcriptase can reduce the amount of the virus in your blood.

How should I take tenofovir disoproxil fumarate?

Take tenofovir DF according to your health care provider’s instructions. Your health care provider will tell you how much tenofovir DF to take and when to take it. Before you start tenofovir DF and each time you get a refill, read any printed information that comes with your medicine.

How should tenofovir disoproxil fumarate be stored?

  • Store tenofovir DF tablets and oral powder between 59°F and 86°F (15°C to 30°C).
  • Keep tenofovir DF in the original container.
  • Do not use tenofovir DF if the seal over the bottle opening is broken or missing.
  • Keep the tenofovir DF medication bottle tightly closed.
  • Safely throw away tenofovir DF that is no longer needed or expired (out of date).
  • Keep tenofovir DF and all medicines out of reach of children.

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