My Cart

0 Item(s): $0.00

You have no items in your shopping cart.

Tenofovir Alafenamide Fumarate

Tenofovir Alafenamide Fumarate


Tenofovir alafenamide fumarate (TAF) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir. Following oral administration, TAF is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5′-monophosphate. Tenofovir mimics normal DNA building blocks but is lacking a 3'-OH molecule required for phosphodiester bond linkage. By competing with regular nucleotides for incorporation into proviral DNA and prevention of the formation of the 5' to 3' phosphodiester linkage required for DNA elongation, tenofovir causes early chain termination and prevents proviral DNA transcription.

What is an tenofovir alafenamide fumarate?

An investigational drug is one that is under study and is not approved by the U.S. Food and Drug Administration (FDA) for sale in the United States. Medical research studies are conducted to evaluate the safety and effectiveness of an investigational drug. These research studies are also called clinical trials. Once an investigational drug has been proven safe and effective in clinical trials, FDA may approve the drug for sale in the United States.

To learn more about investigational drugs, read the AIDSinfo What is an Investigational HIV Drug? fact sheet.

What is tenofovir alafenamide?

Tenofovir alafenamide is a component of an investigational fixed-dose combination (FDC) drug (darunavir/cobicistat/emtricitabine/tenofovir alafenamide) currently being studied for the treatment of HIV infection.3 (FDC drugs include 2 or more drugs in a single dosage form, such as a capsule or tablet.)

Tenofovir alafenamide belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs).2 NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Tenofovir alafenamide fumarate at what price?

The superior safety of the tenofovir analogue tenofovir alafenamide fumarate (TAF) over tenofovir disoproxil fumarate (TDF) would justify a price premium of at most $1,010 per patient per year, according to an analysis published in the online edition of Clinical Infectious Diseases. The authors used pessimistic assumptions about the toxic effect of TDF on kidney function and bone mineral density, so this figure could be revised downwards if it causes fewer serious side effects. Moreover, price comparisons were made between TAF- and branded TDF-containing regimens, and the analysis will need to be repeated when TDF comes off patent in 2017.

Side Effects

  • Backache
  • Chronic Trouble Sleeping
  • Cough
  • Diarrhea
  • Dizzy
  • Feel Like Throwing Up
  • Feeling Weak
  • Fever
  • Head Pain
  • Intense Abdominal Pain
  • Itching
  • Pain
  • Throwing Up


Before taking tenofovir alafenamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, HIV infection, other liver problems (such as hepatitis C, cirrhosis), bone problems (such as bone disease, bone loss/osteoporosis, weak/broken bones), disease of the pancreas (pancreatitis).


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised September 2017. Copyright(c) 2017 First Databank, Inc.

Know More About This Medicine and Buy Now :