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Tenofovir

Tenofovir

What is tenofovir?

Tenofovir is a prescription drug. It comes as an oral tablet and oral powder.

 Tenofovir oral tablet is available as a generic drug and as the brand-name drugs Viread and Vemlidy.

 This drug is used as part of a combination therapy. That means you’ll likely take this drug in combination with other drugs to treat your condition.

Tenofovir (Viread) is an antiviral drug that is approved for the treatment of HIV infection. It is able to reduce the amount of HIV in the blood, help prevent or reverse damage to the immune system and reduce the risk of AIDS-related illnesses. It is also an experimental treatment for hepatitis B .

Why it’s used

Tenofovir is used to treat:

HIV infection, in combination with other antiretroviral drugs. This drug doesn’t eliminate the virus entirely, but it helps to control it.

chronic hepatitis B virus infection.

Used

Tenofovir comes as a tablet and as an oral powder to take by mouth. The tablet is usually taken with or without food once daily. The powder is usually taken with food once daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tenofovir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Tenofovir oral powder must be added to 2 to 4 ounces of soft food such as applesauce, baby food, or yogurt. Stir the mixture with a spoon until well mixed. Consume the mixture right away to avoid a bitter taste. Do not mix tenofovir oral powder with liquid.

How it works

Tenofovir belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). It’s also a hepatitis B virus reverse transcriptase inhibitor (RTI). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Tenofovir works in the same way for both HIV infection and chronic hepatitis B virus infections. It blocks the effectiveness of reverse transcriptase, an enzyme required for each virus to make copies of itself. Blocking reverse transcriptase can reduce the amount of the virus in your blood.

infection

This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.

If you have hepatitis B virus infection and take tenofovir but then stop taking it, your hepatitis B could flare up and become worse.

WARNING:

If you have hepatitis B virus infection (HBV; an ongoing liver infection) and you take tenofovir, your condition may suddenly worsen when you stop taking this medication. Tell your doctor if you have or have ever had HBV. Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to tenofovir.

How should I take tenofovir disoproxil fumarate?

Tenofovir DF (brand name: Viread) comes in the following forms and strengths:

  • 150-mg tablets
  • 200-mg tablets
  • 250-mg tablets
  • 300-mg tablets
  • Oral powder (40 mg of tenofovir DF per 1 g of powder)

Take tenofovir DF according to your health care provider's instructions.

Tenofovir DF tablets should be swallowed whole and can be taken with or without food. People who are unable to swallow the tablets whole may take the oral powder.

How should tenofovir disoproxil fumarate be stored?

Store tenofovir DF at room temperature, 68°F to 77°F (20°C to 25°C).

 Keep tenofovir DF in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.

Do not use tenofovir DF if the original seal over the container opening is broken or missing.

Throw away tenofovir DF that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.

What should I do if I forget a dose?

If you miss a dose of tenofovir DF, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

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