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Tamsulosin Mechanism Of Action

Tamsulosin Mechanism Of Action

Mechanism of Action

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

Absorption

Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.

Common use

Tamsulosin is used to treat Benign prostatic hyperplasia (BPH) also known as benign enlargement of the prostate (BEP). This medicine helps to control your symptoms, diminish urinary retention and reduce your risk of needing the surgery.

Dosage and direction

Take Flomax by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine.

Consult your doctor concerning the proper dose for you.

Precautions

Before taking Flomax tell your doctor or chemist if you are allergic to Tamsulosin; or if you have other allergies.

As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Missed dose

If you have missed your dose, take it as soon as you remember. If you see that it is practically the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store them in the bathroom. Keep all drugs away from children and pets.

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