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Tamsulosin Dosage

Tamsulosin Dosage

Description

Tamsulosin is an Alpha-adrenoreceptor antagonist which is used in men to decrease the urine outflow resistance due to an enlarged prostate gland. This medicine should be used with caution as it may lower the blood pressure. It is not recommended in patients with a known history of allergy to tamsulosin and patients with a risk of erectile dysfunction

Uses of Tamsulosin 0.4mg:

Tamsulosin Is Used In Benign Benign Prostatic Hyperplasia For Improving Urination . Due To Enlarged Prostate , The Neck Of Urinary Bladder Gets Obstructed And Urination Becomes Difficult And Painful. Tamsulosin Helps In Relaxing The Bladder Muscles Thus Opening The Mouth Of Urinary Bladder And Easing Urination .

Side Effects of Tamsulosin 0.4mg:

Postural Hypotension, Dizziness And Vertigo, Malaise, Headache, Rhinitis, Pharyngitis, Cough, Sinusitis, Diarrhoea, Nausea, Infection, Asthenia, Back Pain, Tooth Disorder, Chest Pain, Somnolence, Insomnia, Decreased Libido, Abnormal Ejaculation, Priapism, Blurred Vision. Risk Of Intraoperative Floppy Iris Syndrome During Phacoemulsification Surgery.

Drug Interactions of Tamsulosin 0.4mg:

Concomitant Admin With Moderate Or Strong Inhibitors Of CYP2D6 (Eg. Fluoxetine) Or CYP34A (Eg. Ketoconazole, Cimetidine) Increases Serum Concentration.

Contraindications of Tamsulosin 0.4mg:

Hypersensitivity To Sulfonamide, Severe Hepatic Impairment, Lactation.

Mechanism of Action of Tamsulosin 0.4mg:

Tamsulosin Is A Selective Α1 Adrenoreceptor-Blocking Agent. Smooth Muscle Tone Is Mediated By The Sympathetic Nervous Stimulation Of Α1 Adrenoreceptors, Which Are Abundant In The Prostate, Prostatic Capsule, Prostatic Urethra, And Bladder Neck. Blockade Of These Adrenoceptors Can Cause Smooth Muscles In The Bladder Neck And Prostate To Relax, Resulting In An Improvement In Urine Flow Rate And Reduction In Symptoms In BPH. Absorption: Completely Absorbed From The GI Tract. Peak Plasma Concentrations After 1 Hr; 6 Hr (Modified-Release Preparation). Distribution: Protein-Binding: 99%. Metabolism: Metabolised Slowly In The Liver Primarily By CYP2D6 And CYP3A4. Excretion: Excreted In Urine (76%) And Faeces (21%). Plasma Elimination Half Life: 4-5.5 Hr; As Modified-Release Preparation : 10-13 Hr.

Special Precautions for Tamsulosin 0.4mg:

Prostate Carcinoma Should Be Ruled Out Before Starting The Therapy. Risk Of Intraoperative Floppy Iris Syndrome In Patients Who Undergo Cataract Surgery. May Cause Orthostatic Hypotension Or Syncope Especially With First Dose, If Dosage Is Increased Or An Antihypertensive Drug Or A Phosphodiesterase-5 Inhibitor Is Added To The Treatment Regimen. Caution When Used In Patients With Sulfa Allergy. May Cause Priapism (Rare); Immediate Medical Attention Is Recommended. Pregnancy.

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