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Tamsulosin + Finasteride

Tamsulosin + Finasteride

Description

The treatment of benign prostatic hyperplasia (BPH) that causes lower urinary tract symptoms has advanced enormously since the days when it was a simple choice between no treatment with reassurance, and transurethral resection of the prostate (TURP). Improvements in treatment arose from our recognition that one of the commonest urologic conditions affecting men required other therapeutic options that fitted somewhere between these two extremes. This, in turn, led to a huge amount of laboratory and clinical research that increased our understanding of BPH, and the number of pharmacologic and technological treatments available.

Uses

Finasteride Is Used In The Treatment Of Benign Prostatic Hypertrophy (A Chronic Condition In Which Prostate Size Increases In Men ) . In Lower Doses Finasteride May Also Be Indicated For Growth Of Hair. Tamsulosin Relaxes The Muscles Of Urinary Bladder Neck, Thus Helps In Improved Urination .

Side Effects

Gynaecomastia, decreased libido, impotence, reduction in the vol of ejaculate, genital abnormalities in the male foetus of pregnant women exposed to finasteride. Hypersensitivity reactions such as swelling of lips and rashes, postural hypotension, dizziness and vertigo; headache, infection, asthenia, back pain, chest pain, dizziness, somnolence, insomnia, decreased libido, rhinitis, pharyngitis, cough, sinusitis, diarrhoea, nausea, tooth disorder, amblyopia.

Precautions

Avoid exposure of pregnant women to finasteride, either via direct contact with crushed tab or through semen of male sexual partners who are on this drug. Undiagnosed prostate cancer, liver diseases. Prostate carcinoma should be ruled out before starting the therapy. Hepatic impairment.

Drug Interactions

Caution when used with cimetidine or warfarin. Not to be used with other alpha-adrenergic blocking agents.

Interactions

Food Interaction

Food may delay the rate and reduce the extent of oral absorption, delaying in the time to reach max concentration.

Dosage

  • Oral
  • Benign prostatic hyperplasia
  • Adult: Each capsule contains finasteride 5 mg and tamsulosin 0.4 mg: 1 capsule once daily.

Contraindications of Finasteride 5mg + Tamsulosin 0.4mg:

Children, Exposure Of Pregnant Women To Finasteride Either Via Direct Contact With Crushed Tab Or Through Semen Of Male Sexual Partners Who Are Taking Finasteride; Pregnancy, Lactation.

Mechanism of Action of Finasteride 5mg + Tamsulosin 0.4mg:

Finasteride Is A Competitive Inhibitor Of The Enzyme 5-Α Reductase Which Converts Testosterone To Dihydrotestosterone (DHT), Thus Resulting In Decreased Serum Levels Of DHT. Absorption: Absorbed From The GI Tract (Oral); Peak Plasma Concentrations After 1-2 Hr. Distribution: Protein-Binding: 90%. Metabolism: Hepatic. Excretion: Urine And Faeces (As Metabolites); <60 Yr: 6 Hr; >70 Yr: 8 Hr (Elimination Half-Life).

Conclusion                       

The exact place of the combination therapy in medical management of BPH remains to be precisely determined, as now a days the concept of BPH as the disease is changing fast. BPH is no longer considered as a simple benign enlargement of the prostate gland, but is a chronic, complex disease, which may need more than one agent to take care of the different symptomatologies i.e., LUT, BOO, PSA and sex health.

The data from our study gives some rational and convincing results in favour of the use of a combined treatment for BPH (Tamsulosin and Dutasteride), as this combination is not only safe, well- tolerated with low adverse effects, but also results in much earlier relief of LUTS due to better improvement of IPSS obstructive symptoms, UFR and reduction in PVRU, than observed with the Tamsulosin and Finasteride combination.

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