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Tadalafil Vs Sildenafil

Tadalafil Vs Sildenafil


Sildenafil (Viagra, Revatio) is a moderately priced drug used to treat erection problems in men. It is also used to treat pulmonary arterial hypertension, a serious heart and lung condition. This drug is more popular than comparable drugs. It is available in generic and brand versions. Generic sildenafil is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

What are Cialis and Viagra?

Cialis (tadalafil) and Viagra (sildenafil) are oral drugs that are used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). They are in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes vardenafil (Levitra, Staxyn ODT), and avanafil (Stendra).

Penile erection is caused by the engorgement of the penis with blood. Under normal conditions, sexual stimulation leads to the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis. Cialis and Viagra inhibit an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. Thus, Cialis and Viagra prevent the destruction of cGMP and allows cGMP to accumulate and persist longer. The longer cGMP persists, the more prolonged the engorgement of the penis.

What are the side effects of Cialis and Viagra?

The most common side effects of tadalafil are:

  • facial flushing (reddening),
  • headaches,
  • stomach upset,
  • diarrhea,
  • flu-like symptoms, and
  • nausea.
  • Tadalafil also may cause low blood pressure,
  • blurred vision,
  • changes in color vision, and
  • abnormal ejaculation.

How does Cialis work?

In order to understand how Cialis works, you need to understand what biological mechanisms cause erection in men. Sexual stimulation enhances blood circulation in your pelvic area, which allows more blood to enter the body of your penis making it swell and get harder. There are two chemicals involved in the conversion of nerve signals during sexual stimulation into changes in blood circulation. The first of them is nitric oxide, which is released by nerve endings.

How they both work

Both Cialis and Viagra belong to a class of drugs called PDE-5 inhibitors. So, when men are sexually aroused, the meds work by increasing the blood flow into penile tissues and maintaining relaxed muscle state, thus, allowing users to get and maintain stronger erections. However, these meds don’t increase men’s sexual drive, so they should be taken only to treat problems associated with male impotence.