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About Sulfasalazine (Azulfidine)

Sulfasalazine (Azulfidine) is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis, prevent joint damage, and reduce the risk of long-term disability. Sulfasalazine is in a type of sulfa drug. You should not take it if you have a sulfa allergy. Sulfasalazine is used in the treatment of rheumatoid arthritis (RA), inflammatory bowel disease, and some other autoimmune conditions. It works to lower inflammation in the body.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

How does Sulfasalazine work?

It is believed that Sulfasalazine starts working when it reaches the intestines, and provides topical relief there. It does so by reducing the synthesis of inflammatory mediators known as eicosanoids and inflammatory cytokines.

What other drugs will affect Sulfasalazine?

Sulfasalazine may decrease the absorption of digoxin. Sulfasalazine may also decrease the absorption of folate (folic acid). Drugs other than those listed may also interact with Sulfasalazine. Talk to your veterinarian or pharmacist before giving prescription or over-the-counter medications.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Side Effects Associated With Using Sulfasalazine?

  • Loss of appetite
  • Headache
  • Nausea
  • Vomiting
  • Gastric distress/stomach upset
  • Temporary, reversible male infertility

Sulfasalazine Warnings

Before taking sulfasalazine, tell your doctor if you have or have ever had:

  • Asthma
  • Kidney or liver disease
  • Porphyria (a blood disorder)
  • Other blood problems (such as anemia or low white blood cell levels)
  • Rheumatoid arthritis
  • Thyroid problems