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Spironolactone

Spironolactone

Why is this medication prescribed?

Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Spironolactone is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

Spironolactone for Acne

Spironolactone is sometimes used off-label to treat women with persistent adult acne due to increased androgen levels, because the drug is able to inhibit the activity of sebaceous glands (small skin glands that releases an oily, lubricating substance called sebum).

The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess.

Spironolactone Interactions

Always tell your doctor about any legal and illegal drugs, supplements, and herbal remedies you are taking.

Spironolactone can have a negative interaction with the following drugs:

  • Lithium (Eskalith, Lithobid)
  • ACE inhibitors, such as benazepril (Lotensin)
  • Angiotensin II receptor blockers, such as azilsartan (Edarbi)
  • Digoxin (Lanoxin)

Dosages Of Spironolactone

Adult and Pediatric Dosage Forms and Strengths

Tablet

  • 25 mg
  • 50 mg
  • 100 mg

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Precautions

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Older adults may be more sensitive to the side effects of this drug, especially the effects on potassium (see Side Effects section).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

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