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Sitagliptin Drug Class

Sitagliptin Drug Class

Sitagliptin Overview

Sitagliptin is a prescription medication used to treat type 2 diabetes in adults.

Sitagliptin belongs to a group of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, which help lower blood sugar levels.

This medication comes in tablet form and is taken once a day, with or without food.

Common side effects include upper respiratory infection, stuffy nose, sore throat, nausea, and diarrhea.

Uses of Sitagliptin

Sitagliptin is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Sitagliptin Brand Names

Sitagliptin may be found in some form under the following brand names:

  • Januvia

Sitagliptin Drug Class

Sitagliptin is part of the drug class:

  • Dipeptidyl peptidase 4

How is this medicine (Sitagliptin) best taken?

Use sitagliptin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • To gain the most benefit, do not miss doses.
  • Keep taking sitagliptin as you have been told by your doctor or other health care provider, even if you feel well.

How it works

Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Insulin is a chemical in your body that helps remove sugar from your blood and moves it to cells, where it can be used for energy. Hormones in your body called incretins regulate the production and release of insulin. Sitagliptin works by protecting incretin hormones so they aren’t broken down too quickly. This helps your body use insulin better and lowers your blood sugar.

Important warnings

Pancreatitis warning: Sitagliptin may increase your risk of pancreatitis (inflammation of the pancreas). This can be severe and sometimes fatal. Before you start taking this drug, tell your doctor if you’ve ever had:

  • pancreatitis
  • gallstones (stones in your gallbladder)
  • alcoholism
  • high triglyceride levels
  • kidney problems

Joint pain warning: This drug may cause severe and disabling joint pain. Tell your doctor right away if you have joint pain while taking this drug. Your doctor may switch you to another medication to control your diabetes.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Pancreatitis. Symptoms can include:

  • severe pain in your stomach that won’t go away, and that can be felt from your stomach through your back
  • vomiting

Low blood sugar.* Symptoms can include:

  • intense hunger
  • nervousness
  • shakiness
  • sweating, chills, and clamminess
  • dizziness
  • fast heart rate
  • lightheadedness
  • sleepiness
  • confusion

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