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Sitagliptin Cost

Sitagliptin Cost

What is Januvia

Januvia (generic name is sitagliptin) reduces blood glucose in individuals with type 2 diabetes by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). DPP-4 inhibitors increase the amount of two proteins (incretin hormones) found in the body, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretin hormones tell the body to release insulin and lower blood glucose. GLP-1 also decreases the production of glucose and slows down the absorption of glucose.

Incretin hormones are removed from the body by an DPP-4. DPP-4 inhibitors like Januvia block this enzyme resulting in GLP-1 and GIP to stay in the body longer and therefore decrease blood glucose levels.

What is Januvia used for

Januvia is used for treating type 2 diabetes in combination with diet and exercise. It is not used for treating type 1 diabetes. It can be combined with metformin or sulfonylurea.

How effective is Januvia

Januvia reduced hemoglobin A1C by -0.6% after 24 weeks while A1C increased by 0.2% in the placebo group.

36% of individuals treated with Januvia achieved A1C less than 7% after 24 weeks compared to 14% of individuals treated with placebo.

What is the cost of Januvia

Cost between $11 and $14 per tablet per tablet.

Side effects of Januvia tab

  • Metabolic: Low blood sugar with other medications.
  • Central Nervous System: Headache.
  • Eye and ENT: Inflammation of nasopharynx.
  • Gastrointestinal: Diarrhea, nausea, inflammation of pancreas.
  • Respiratory: Upper respiratory tract infection.
  • Musculoskeletal:Joint pain, muscle pain, pain in extremity and back pain.

Mechanism of Action of Sitagliptin 100mg:

Sitagliptin Inhibits Dipeptidyl Peptidase IV (DPP-IV), Resulting In Prolonged Active Incretin Levels. Incretin Hormones Increases Insulin Synthesis And Release From Pancreatic Β-Cells And Reduces Glucagon Secretion From Pancreatic Α-Cells. Reduced Glucagon Secretion Leads To Decreased Hepatic Glucose Production. Absorption: Rapid Absorption. Bioavailability: About 87%. Distribution: Protein Binding: 38%. Metabolism: Not Extensively Metabolised. Excretion: Elimination Half-Life: 12 Hr. 87% Excreted In Urine (Mainly As Unchanged Drug) And 13% Excreted In Faeces.


Certain drugs may interact with Janumet and result to increased risks of side effects. These drugs may also lessen the effectiveness of Janumet. Drugs that are prone to interacting with Janumet are ciclosporin, digoxin, cimetidine, clarithromycin, insulin, itraconazole, ritonavir, probenecid and ketoconazole. Other drugs that could negate the effectiveness of Janumet are ACE inhibitors, diuretics, beta-agonists, sulphonylureas, organic anion transporter-3 inhibitors and iodinated contrast media. Patients are advised to inform their doctors beforehand prior to taking Janumet.

Generic Alternatives

People who can’t take Janumet due to certain reasons like recurring side effects could opt for generic alternatives like insulin and other injectable diabetes medications. Lifestyle changes like maintaining a healthy diet and regular exercise are also recommended.

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