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Simvastatin Sitagliptin

Simvastatin Sitagliptin

Descriptions

Sitagliptin and simvastatin combination is used together with a proper diet and exercise to treat type 2 diabetes. It is also used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems caused by clogged blood vessels such as heart attacks and strokes.

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

Uses For sitagliptin and simvastatin

Sitagliptin and simvastatin combination is used together with a proper diet and exercise to treat type 2 diabetes. It is also used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. Sitagliptin and simvastatin may help prevent medical problems caused by clogged blood vessels such as heart attacks and strokes.

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

Simvastatin belongs to the group of medicines called statins. It works to reduce the amount of cholesterol in the blood by blocking the production of cholesterol.

Sitagliptin and simvastatin was available only with your doctor's prescription. The Juvisync™ product will no longer be marketed in the United States as of September 26, 2013, but may be available in other countries.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • Breathing problems
  • Confusion
  • Dark urine
  • Fever
  • Joint pain
  • Light-colored stools
  • Loss of appetite
  • Loss of memory
  • Low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
  • Muscle cramps, pain
  • Redness, blistering, peeling or loosening of the skin, including inside the mouth
  • Right or left upper belly pain
  • Trouble passing urine or change in the amount of urine
  • Unusually weak or tired
  • Unusual stomach pain or discomfort
  • Vomiting

Dosage Modifications

Coadministration with dronedarone, verapamil, or diltiazem: Do not exceed simvastatin 10 mg/day

Coadministration with amiodarone, amlodipine or ranolazine: Do not exceed simvastatin 20 mg/day

Coadministration with grapefruit juice: Avoid large quantities of grapefruit juice (ie, >1 quart/day)

Patients with homozygous familial hypercholesterolemia: 100 mg/40 mg PO qDay in the evening (or 50 mg/40 mg with renal impairment); and should be used as an adjunct to other lipid lowering treatment

Chinese patients taking lipid-modifying doses of niacin (ie, ≥1 g/day): Increased risk of myopathy with simvastatin 40 mg/day; consider lower dose

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