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Silodosin

Silodosin

What is silodosin?

Silodosin is a prescription medication. It comes as an oral capsule.

Silodosin oral capsule is available as the brand-name drug Rapaflo. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Silodosin may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it’s used

Silodosin is used to treat the symptoms of benign prostatic hyperplasia (BPH) in adult men. This condition is also called enlarged prostate. It helps lessen your BPH symptoms and improve your ability to urinate.

  • When the prostate is enlarged, it can pinch or squeeze your urethra and affect your ability to urinate. This may cause:
  • nighttime urination (nocturia)
  • sudden urge to urinate
  • frequent urge to urinate
  • difficulties in starting to urinate
  • feeling like you can’t completely empty your bladder
  • weak urine flow
  • straining while urinating
  • dribbling (leaking) after urination

How it works

This drug belongs to a class of drugs called alpha-1 blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Alpha-1 receptors are located in your prostate and bladder. They’re responsible for the contraction of the smooth muscles of the bladder and prostate. Silodosin blocks these receptors, which causes the smooth muscles in the prostate and bladder to relax. This will reduce your BPH symptoms and improve your ability to urinate.

More common side effects

The more common side effects that can occur with silodosin include:

  • dizziness
  • diarrhea
  • orthostatic hypotension (low blood pressure when you stand up after sitting or lying down)
  • headache
  • retrograde ejaculation (occurs when semen enters the bladder instead of out the tip of the penis)
  • common cold
  • stuffy nose
  • Mild side effects may disappear within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Warnings for people with certain health conditions

For people with kidney disease: Your body gets rid of this drug partly through your kidneys. If your kidneys aren’t working well, more of the drug may stay in your body. This increases your risk of side effects. This drug isn’t recommended if you have severe kidney disease. If you have moderate kidney disease, your doctor may give you a lower dosage.

For people with liver disease: This drug is processed by your liver. If your liver isn’t working well, more of the drug may stay in your body. This increases your risk of side effects. This drug isn’t recommended if you have severe liver disease, because it hasn’t been studied in people with this condition.

For people with low pressure (hypotension): This drug may cause low blood pressure when you stand up after sitting or lying down, dizziness, and even further lowering of your blood pressure. Don’t drive, use machinery, or perform dangerous tasks until you know how it affects you.

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