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Sildenafil Wiki

sildenafil wiki

about sildenafil wiki

Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.Its effectiveness for treating sexual dysfunction in women has not been demonstrated.

Common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a severe and potentially fatal drop in blood pressure.

Mechanism of action

Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection. Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

Uses of Viagra

Viagra is a prescription medication used to treat erectile dysfunction (ED) in adult males.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Viagra

The most common side effects of Viagra are:

headache

flushing of the face

upset stomach

Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision.

Viagra Precautions

Viagra is not for newborns, children, or women.

Do not let anyone else take your Viagra.

Viagra must be used only under a doctor's supervision.

There is potential risk of sexual activity in patients with cardiovascular risk factors. If you experience symptoms (chest pain, dizziness, nausea) upon initiation of sexual activity, it is advised to refrain from further sexual activity and discuss the episode with your doctor.

Viagra can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke.

Viagra Dosage

For the treatment of ED:

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Viagra may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Your doctor may increase the dose to a maximum recommended dose of 100 mg or decreased it to 25 mg. Viagra is to be taken only once per day.

Viagra Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

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