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Sildenafil Vs Tadalafil

Sildenafil Vs Tadalafil

What are Cialis and Viagra?

Cialis (tadalafil) and Viagra (sildenafil) are oral drugs that are used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). They are in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes vardenafil (Levitra, Staxyn ODT), and avanafil (Stendra).

Penile erection is caused by the engorgement of the penis with blood. Under normal conditions, sexual stimulation leads to the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis. Cialis and Viagra inhibit an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. Thus, Cialis and Viagra prevent the destruction of cGMP and allows cGMP to accumulate and persist longer. The longer cGMP persists, the more prolonged the engorgement of the penis.

Aims

Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED.

Methods

We designed a strategy for searching the PubMed, Embase, EBSCO, Web of Science and Cochrane library databases; the reference lists of the retrieved studies were also investigated. A literature review was performed to identify all published randomized or non-randomized controlled trials that compared tadalafil with sildenafil for the treatment of ED and to assess the quality of the studies. Two investigators independently and blindly screened the studies for inclusion. The meta-analysis was performed using RevMan 5.0.

How do Tadalafil and Viagra work?

Tadalafil, like Sildenafil is what is known as a PDE-5 inhibitor. When sexually stimulated, the PDE-5 class of drugs maintains a relaxed muscle state and increases the flow of blood to the penis to facilitate an erection. PDE-5 inhibitors do not increase interest or sexual desire and are only used to treat the physical problems associated with erectile dysfunction.

Does Tadalafil work more quickly than Sildenafil?

Although both have a fast onset of action, Tadalafil works slightly faster than Sildenafil. While Sildenafil usually takes about 20-30 minutes, Tadalafil can work in 15-20 minutes. Tadalafil is also available as Tadalafil Daily, which is taken once a day, and will enable you to achieve an erection anytime throughout the day.

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