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sildenafil nitrate

sildenafil nitrate

What Are Nitrates?

Nitrates or nitrovasodilators belong to the group of medications with vasodilatory features and varying in their chemical structure. Nitrates are united by operation mechanism: as a result of complex chemical transformations all nitro-vasodilators turn into nitrogen oxide (NO). NO is a substance analogous to the so-called endothelium-dependent relaxant.  Nitrogen oxide activates guanylate cyclase causing production of cyclic guanosine monophosphate capable to relax vascular smooth muscle cells.

How Viagra works

Viagra belongs to a group of medicines called phosphodiesterase type 5 inhibitors (PDE5 inhibitors).

It works by relaxing the blood vessels in your penis when you are sexually excited. This allows blood to flow into your penis, allowing you to get an erection in a natural way.

The physiological mechanism responsible for the erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme, guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

Viagra tablets contain sildenafil (as citrate) equivalent to 25 mg, 50 mg or 100 mg sildenafil.

Side Effect

Major and Minor sildenafil nitrate Side Effect

  • hives
  • difficulty breathing
  • swelling on the face, lips, throat or tongue
  • vision loss
  • ring in the ear
  • chest pain
  • irregular heartbeat
  • swelling in limbs
  • shortness of breath
  • vision changes
  • penis erection for over 4 hours
  • light headedness
  • stuffy nose
  • headache
  • memory problems
  • upset stomach
  • back pain

Nitrates Combined With Other Remedies

The enhancement of hypotensive action is shown while combining nitrates with barbiturates, opioids, tricyclic antidepressants, and other medicines decreasing arterial blood pressure. Reduction of vasolidating effect is possible due to the one-time intake of organic nitrates along with carbacholinum, norepinephrine, phenylephrine, histamine, angiotensin, CNS stimulants, M-cholinoblockers (atropine). Phenobarbital activates hepatic metabolism of nitrates resulting in reduction of their bioaccessibility in medical forms for peroral intake.

How to take Viagra

Take Viagra exactly as your doctor has prescribed. Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained here.

If you do not understand the instructions on the box, ask your doctor or pharmacist for help.


For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Viagra may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

Ask your health care provider any questions you may have about how to use Viagra.


Store Viagra at 77 degrees F (25 degrees C). storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viagra out of the reach of children and away from pets.