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Sildenafil For Pah

Sildenafil For Pah

sildenafil for pah

The therapy of pulmonary hypertension has evolved rapidly in the last 10 years from the use of non-selective vasodilators to drugs that specifically target pulmonary vasodilation, endothelial function, and vascular remodeling. Sildenafil is a phosphodiesterase type 5 inhibitor that has an expanding role in the treatment of pulmonary hypertension. Case series and small studies, as well as the first large randomized controlled trial, have demonstrated the safety and efficacy of sildenafil in improving mean pulmonary artery pressure, pulmonary vascular resistance, cardiac index, and exercise tolerance in pulmonary arterial hypertension.

Uses of Sildenafil Tablets

It is used to treat high blood pressure in the lungs. It may be given to you for other reasons. Talk with the doctor.

How does sildenafil work?

PDE5 is a substance produced in the lungs and other parts of the body that breaks down another substance called cyclic guanosine monophosphate (GMP). Cyclic GMP causes the blood vessels (arteries) to relax and widen. Sildenafil decreases the activity of PDE5, so that more cyclic GMP is available for the blood vessels inside the lungs. This leads to relaxation, or widening, of those vessels. Relaxing and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function. This reduces blood pressure in the lungs which generally results in the ability to be more active. Research studies have verified this improvement.

How can a patient obtain sildenafil?

Sildenafil must be prescribed by a physician, and insurance approval must be obtained prior to starting therapy. It is carried by most retail and specialty pharmacies, including Accredo Health Inc., Aetna Specialty Pharmacy, CVS Caremark, Cigna Tel-Drug, CuraScript, Kaiser Permanente Specialty Pharmacy, Precision Rx, Walgreens Specialty Pharmacy (Medmark) and WellCare.

Side Effect

Major and Minor side effect

  • Nose bleeds
  • Headache
  • Upset stomach and heartburn
  • Flushing of the skin
  • Difficulty sleeping
  • Worsening shortness of breath
  • Nasal congestion.
  • Fluid retention
  • Nausea and diarrhea
  • Pain in the extremity (arm or leg)
  • Temporary muscle aches
  • Fever
  • Numbness

How do I store and/or throw out Sildenafil Tablets?

Store at room temperature.

Store in a dry place. Do not store in a bathroom.

Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

 

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