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Sildenafil Doses

Sildenafil Doses

Usual Adult Dose for:

  • Erectile Dysfunction
  • Pulmonary Hypertension

Usual Geriatric Dose for:

  • Erectile Dysfunction

Additional dosage information:

  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Erectile Dysfunction

Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity
Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activity
Comments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity.
Use: Treatment of erectile dysfunction

Usual Adult Dose for Pulmonary Hypertension

OralInitial dose: 5 or 20 mg orally three times a day, 4 to 6 hours apart

Maximum dose: 20 mg orally three times a day
Injection:Initial dose: 2.5 or 10 mg IV bolus three times a day
Comments:No greater efficacy was achieved with oral doses higher than the maximum recommended dose 
10 mg injection dose is predicted to provide pharmacological effect equivalent to the 20 mg oral dose.
Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening

Usual Geriatric Dose for Erectile Dysfunction

Initial dose: 25 mg orally once a day 1 hour prior to sexual activity

Use: Treatment of erectile dysfunction

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 to less than 80 mL/min): No adjustment recommended.

Severe renal dysfunction (CrCl less than 30 mL/min): 25 mg orally once a day 1 hour prior to sexual activity


 

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