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Sildenafil Contraindication

Contraindications of Sildenafil

Sildenafil citrate is a drug used for the treatment of male impotence. The drug is popularly known as Viagra or blue pill and it is the most popular medicine in the world since last 2 decades. This medicine has saved thousands of relationships and millions of men from embarrassment of erectile dysfunction.

However, from a past few years individuals have started abusing this drug. There are many myths related to the drug and these myths have promoted the over use and abuse of the medicine. As a result, patients are getting more side-effects than the optimum results. The side-effects in turn affect the performance of the male individual in the bedroom.

Mostly, this medicine is considered as boost for sexual performance for males contrary to the fact that sildenafil is a drug that has its own side-effects, limitations and contraindications. Contraindications of sildenafil can be in form of cautions where one has to be careful while administering the medicine. On the other hand, there are cases in which an individual cannot use this medicine or there can be serious side effects and fatal end results after consumption of the medicine. Below are the cases in which Viagra is contraindicated in men:

Sildenafil is contraindicated in case the patient is consuming medicines classified under nitrates, organic nitrites and nitric oxide donors. Examples of such medicines include sodium Nitroprusside, amyl nitrite and glyceryl trinitrate.

Sildenafil should not be consumed in cases where sexual activity is prohibited by doctors due to medical conditions affecting the cardiovascular health. Sildenafil will increase the blood flow in this case and as a result heart will exert that may lead to severe complications.

Sildenafil potentiates the hypotensive effect of nitrates

Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of sildenafil. Most, but not all, of these patients had pre-existing cardiovascular risk factors. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of sildenafil without sexual activity. It is not possible to determine whether these events are related directly to these factors or to other factors.

Interactions:

See Contraindications. Hypotension with nitrates, GC stimulators. Additive hypotensive effects with concomitant α-blockers (eg, doxazosin), antihypertensives (eg, amlodipine). Potentiated by CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, saquinavir, ritonavir) or CYP2C9 inhibitors, or cimetidine. Antagonized by CYP3A4 inducers (eg, rifampin). Concomitant other erectile dysfunction treatments: not recommended.

Warnings/Precautions:

Confirm diagnosis. Cardiovascular disease (eg, MI, stroke, or life-threatening arrhythmia within 6 months; BP<90/50 or >170/110; unstable angina, LV outflow obstruction, impaired autonomic regulation of BP). Anatomical penile deformation. Predisposition to priapism. History of non-arteritic anterior ischemic optic neuropathy (NAION) or those with "crowded" optic disc. Retinitis pigmentosa. Advise patients to discontinue if sudden vision or hearing loss occurs. Patients for whom sexual activity is inadvisable or contraindicated. Bleeding disorders. Active peptic ulcer.

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