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Sildenafil And Nitrates

Sildenafil And Nitrates


sildenafil and nitrates is indicated for the treatment of erectile dysfunction. Large and sudden decreases in systemic blood pressure were reported in a substantial number of patients taking sildenafil citrate combined with nitroglycerin. We studied the effect of sildenafil citrate on the relationship between changes in systemic blood pressure and coronary blood flow.

What are sildenafil and nitrates ?

sildenafil and nitrates have been the basis for the treatment of angina for decades. Angina is an uncomfortable feeling, tightening or pain in your chest that can spread to your arms, back, jaw, neck or stomach. It is caused by narrowing, blockage or spasms within the coronary arteries, which limits the amount of oxygenated blood reaching part of your heart muscle.

Essentially, nitrates dilate – that is, widen or relax – the arteries and the veins not only in the heart but also elsewhere in the body. By dilating the blood vessels of the heart, nitrates can reduce the stress on the heart by improving blood flow to the heart muscle. This will relieve angina symptoms.Effects

The effects of sildenafil plus ISMN on BP (standing mean maximum reductions from baseline in were greater than the effects of placebo plus ISMN on BP .Sildenafil plus GTN also resulted in greater sitting mean maximum reductions from baseline in systolic/diastolic BP compared with placebo plus GTN .

How do sildenafil and nitrates work?

Nitrates are vasodilators (dilators of blood vessels that increase their diameter) that allow blood to flow more easily. Blood returning from the body in the veins must be pumped by the heart through the lungs and into the body's arteries against the high pressure in the arteries. In order to accomplish this work, the heart's muscle must produce and use energy ("fuel"), and this requires consumption of oxygen that is supplied by the blood. Angina (angina pectoris or "heart pain") is due to an inadequate flow of blood (and oxygen) to the muscle of the heart.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

  • Rare
  • Skin rash
  • unusual tiredness or weakness
  • Signs and symptoms of overdose
  • Bluish-colored lips, fingernails, or palms of hands
  • dizziness (extreme) or fainting
  • feeling of extreme pressure in head
  • shortness of breath
  • unusual tiredness or weakness
  • weak and fast heartbeat