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Sildenafil 100 Mg Para Que Sirve

Sildenafil 100 Mg Para Que Sirve

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5) specific cyclic guanosine monophosphate (cGMP) of the corpora cavernosa, where PDE5 is responsible for the degradation of cGMP.

Therapeutic indications Sildenafil

Erectile dysfunction. Tto. of pulmonary arterial hypertension classified as functional grade II and IIII of the WHO (efficacy has been demonstrated in pulmonary hypertension 1 aria and pulmonary hypertension associated with connective tissue of the connective tissue). Tto. 
children from 1 to 17 years with pulmonary arterial hypertension (demonstrated efficacy in terms of improved exercise capacity or pulmonary hemodynamics in pulmonary hypertension 1 and pulmonary hypertension associated with congenital heart disease). Track IV: tto. in ads. with pulmonary arterial hypertension who temporarily can not receive oral therapy, but who are clinically and hemodynamically stable.

Contraindications Sildenafil

Hypersensitivity concomitant use with nitrates or nitric oxide donors; severe cardiovascular dysfunctions, unstable angina or insuf. severe cardiac Severe IH; hypotension; recent history of ACV or IAM; retinitis pigmentosa; combination with potent inhibitors of CYP3A4 (ketoconazole, itraconazole, ritonavir); patients who present with loss of vision due to a non-arteritic anterior ischemic optic neuropathy regardless of whether this episode was associated or not with previous exposure to a PDE5 inhibitor.

Warnings and precautions Sildenafil

IR serious; Mild IH; anatomical deformations of the penis (angulation, cavernous fibrosis or Peyronie's disease) or predisposition to priapism (sickle cell anemia, multiple myeloma or leukemia); hemorrhagic disorders or with active peptic ulcer. Consider cardiovascular status, due to a cardiac risk associated with sexual activity. Not recommended in combination with alpha blockers, or with other tto. for erectile dysfunction. Stop if a sudden visual disturbance occurs. Not recommended in children and <18 years. In pulmonary arterial hypertension there may be> risk of hemorrhage in patients with tto. of vit antagonist. K and in case of interrupting the tto. gradual dose reduction is recommended. Warnings and precautions concomitance with other tto. for pulmonary arterial hypertension (bosentan, iloprost); it should not be used in patients with pulmonary arterial hypertension secondary to sickle cell anemia. Route IV: not recommended in hemodynamically unstable patients; It is not indicated in children <18 years.

Effects on the ability to drive Sildenafil

In the sildenafil clinical trials dizziness and visual disturbances were reported, therefore, patients should know how it can affect them before driving or using machines.Adverse reactions 

 

 

 

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