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Side Effects Of Hydroxyurea 500 Mg

Side Effects Of Hydroxyurea 500 Mg

What Is Hydroxyurea (Hydrea)?

Hydroxyurea is a prescription drug sold under the brand name Hydrea.

It's used to treat psoriasis, chronic myelogenous leukemia (a cancer of the white blood cells), ovarian cancer, melanoma (a form of skin cancer), and certain head and neck cancers.

The medicine also helps people with sickle cell anemia (an inherited blood disorder) by reducing the frequency of painful sickle cell crisis episodes and the need for blood transfusions.

How it works

Hydroxyurea belongs to a class of drugs called antimetabolites. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

In people with cancer, hydroxyurea acts as a substitute for some parts that the cancer cells need to grow. Cancer cells take in hydroxyurea, which stops the cancer cell from growing. Cancer cells grow more rapidly than normal cells, so they are more affected by the drug.

In people with sickle cell disease, this drug changes the shape of red blood cells. This makes it less likely for sickle cell crises to occur.

Hydroxyurea Side Effects

  • Nausea, vomiting, or diarrhea.
  • Loss of appetite.
  • Constipation.
  • Weight gain.
  • Sores in the mouth or throat.
  • Pale skin.
  • Rash.
  • Mild dizziness.
  • stomach pain
  • constipation
  • diarrhea
  • nausea
  • vomiting
  • loss of appetite

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Leukemia. Symptoms can include:
  • more frequent infections than you normally have
  • Skin cancer. Symptoms can include:
  • changes to skin color and texture
  • new moles or bumps on your skin
  • Blood vessel damage. Symptoms can include:
  • developing open sores on your arms or legs


Before taking hydroxyurea, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood/bone marrow disorders (such as bone marrow suppression, neutropenia, thrombocytopenia, anemia), HIV infection, high uric acid level in the blood, radiation treatment.


Hydroxyurea contains a black-box warning because it can cause a severe drop in the number of blood cells in your bone marrow. This can increase your risk of a serious infection or bleeding.

Tell your doctor right away if you experience any of the following symptoms while taking hydroxyurea:

  • Fever, sore throat, cough, congestion, or other signs of infection
  • Unusual bruising or bleeding
  • Vomit that's bloody or looks like coffee grounds
  • Bloody or black, tarry stools


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose include: swelling/scaling of hands and feet.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised June 2018. Copyright(c) 2018 First Databank, Inc.

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