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Side Effects Of Desmopressin

Side Effects Of Desmopressin

Uses

Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have "water diabetes" (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration.

Desmopressin products applied in the nose are no longer indicated to control nighttime bedwetting in children because of the increased risk of developing a serious side effect (a low level of sodium in the blood).

Side effects

  • nausea,
  • vomiting,
  • severe headache,
  • muscle weakness/spasms/cramps,
  • weight gain,
  • unusual tiredness,
  • dizziness,
  • severe drowsiness,
  • mental/mood changes (confusion, hallucinations, irritability),
  • loss of consciousness,
  • seizures, or
  • slow/shallow breathing.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: tolvaptan, "water pills"/diuretics (such as furosemide).

How should I use this medication?

For diabetes insipidus: The usual recommended dose for adults is 10 µg to 40 µg daily. The usual recommended dose for children 3 months to 12 years of age is 5 µg to 30 µg daily. The dose may be given as a single dose or divided into 2 or 3 doses. The lowest effective dosage should be used. Do not drink any fluids for at least 1 hour before taking desmopressin and for 8 hours after using desmopressin.

For preventing bleeding: The usual recommended dose is one 150 µg spray in each nostril, or one 150 µg spray in one nostril for people who weigh less than 50 kg (110 lbs). If it is being used to prevent bleeding related to surgery, it is given 2 hours before surgery.

Precautions

Before using desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, high blood pressure, heart disease (such as blocked blood vessels in the heart), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis, heart failure), the urge to drink too much water without being thirsty, a low level of sodium in the blood (hyponatremia), bleeding/clotting problems.

If you have lost too much body water (become dehydrated), your doctor will correct that condition first before starting treatment with desmopressin.

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