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About Regorafenib

Regorafenib is the generic name for the trade name chemotherapy drug Stivarga®. In some cases, health care professionals may use the trade name Stivarga® when referring to the generic drug name regorafenib.

Drug type: Regorafenib is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor - (For more detail, see "How this drug works," below.)

What Regorafenib Is Used For:

For the treatment of colorectal cancer.

For the treatment of hepatocellular carcinoma (HCC) after prior treatment with sorafenib.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Regorafenib Is Given:

Regorafenib is a pill, taken by mouth, once daily. Take with a low-fat (less than 30% fat) breakfast. Examples of a low-fat breakfast include:

2 slices of white toast with 1 tablespoon of low-fat margarine and 1 tablespoon of jelly, and 8 ounces of skim milk (319 calories and 8.2 grams of fat), or

1 cup of cereal, 8 ounces of skim milk, 1 slice of toast with jelly, apple juice, and 1 cup of coffee or tea (520 calories and 2 grams of fat).

Take regorafenib exactly as prescribed.

Take regorafenib at the same time every day.

Swallow regorafenib tablets whole. Do not crush or dissolve.

Do not change your dose or stop regorafenib unless your health care provider tells you to.

If you miss a dose, take it as soon as you remember. If it is too close to your next dose (within 12 hours), just take your next dose at your regular time.

Do not take more than 1 dose of regorafenib at one time. Call your health care provider right away if you take too much.

The amount of regorafenib that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Side Effects:

  • Important things to remember about the side effects of regorafenib:
  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • Side effects are almost always reversible and will go away after treatment is complete.
  • There are many options to help minimize or prevent side effects.

There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

When you have it

You usually take regorafenib every day, for 3 weeks. Then you have a week with no treatment. This 4 week period is called a cycle of treatment.

Then you start the cycle again.

You usually take regorafenib for as long as it is helping you. Your doctor will tell you:

what dose of regorafenib you need to take

when to take it

how long to take it for

Self-Care Tips:

Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.

You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your healthcare provider.

Wash your hands often.

Ask your doctor or nurse before scheduling dental appointments or procedures.

Use an electric razor and a soft toothbrush to minimize bleeding.

Avoid contact sports or activities that could cause injury.

If you should experience nausea, take anti-nausea medications as prescribed by your doctor, and eat small frequent meals. Sucking on lozenges and chewing gum may also help.

Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.

In general, drinking alcoholic beverages should be avoided completely. You should discuss this with your doctor.

Get plenty of rest.

Maintain good nutrition.

Keep your mouth clean with baking soda and salt rinses. You can mix 1/2 to 1 tsp. of baking soda and/or 1/2 to 1 tsp. salt in 8 ounces of water, and use as a mouthwash, to avoid or decrease the severity of mouth sores.

Regorafenib can cause tiredness, weakness or blurred vision. If you have any of these symptoms, use caution when driving a car, using machinery, or anything that requires you to be alert.

If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.