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Praziquantel

Praziquantel

What Is Praziquantel?

Praziquantel is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Caribbean, and parts of Asia.

Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish.Praziquantel should not be used to treat parasitic infections in the eye.

Praziquantel may also be used for purposes not listed in this medication guide.You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin (Rifadin, Rifater, Rifamate) in the last 4 weeks.

Before taking praziquantel, tell your doctor if you have kidney disease, heart disease, liver disease, or a history of seizures or epilepsy.Do not give this medication to a child younger than 4 years old.Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Praziquantel Interactions

Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.Grapefruit and grapefruit juice may interact with praziquantel and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Tell your doctor about all other medications you are using, especially:

  • cimetidine (Tagamet);
  • chloroquine (Aralen);
  • itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
  • dexamethasone (Decadron, Hexadrol);
  • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
  • St. John's wort;
  • rifabutin (Mycobutin) or rifapentine (Priftin);
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
  • HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with praziquantel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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