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What Is Pramipexole (Mirapex)?

Pramipexole is the generic name for the prescription drug Mirapex, which is used to treat  and restless leg syndrome. Mirapex belongs to a class of drugs called dopamine agonists. Scientists believe that it encourages dopamine activity in the body by increasing the sensitivity.In the brain, dopamine acts helping nerves communicate — which improves movement in restless leg syndrome and helps relax tremors.
Originally manufactured by Boehringer Ingelheim under the brand name Mirapex, pramipexole was first approved by the Food and Drug Administration (FDA) in 1997.

Pramipexole Warnings

Don't take pramipexole if you're allergic to the drug or any of its ingredients.

Ask your doctor about pramipexole if you:

  • Are 65 or older
  • Have kidney problems
  • Have any kind of severe heart disease
  • Drink alcohol regularly
  • Have any kind of sleep disorder

Pramipexole Dosage

Mirapex come in tablets of 0.125 milligrams (mg), 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, and 1.75 mg.Mirapex ER comes in strengths of 0.375 mg, 0.75 mg, 1.5 mg, 2.25 mg, 3 mg, 3.75 mg, and 4.5 mg. Your doctor may start you on 0.375 mg and adjust your dose based on how the drug seems to be working for you.Generic pramipexole comes in most of these strengths for both regular and extended-release formulations.Don't crush, chew, split, or break open extended-release formulations of pramipexole.

You can take pramipexole with or without food, but taking it with food may help prevent nausea as a side effect.Start by taking pramipexole a couple of hours before bedtime, or as your doctor recommends.