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Pioglitazone 30 Mg

pioglitazone 30 mg

What is metformin-pioglitazone?

Metformin/pioglitazone is a prescription drug. It comes in two forms: oral immediate-release tablet and oral extended-release tablet.

Metformin/pioglitazone oral tablet is available as the brand-name drugs Actoplus Met (immediate-release) and Actoplus Met XR (extended-release). The immediate-release tablet is also available as a generic drug. Generic drugs usually cost less than brand-name versions. In some cases, they may not be available in every strength or form as the brand-name drugs.

Metformin/pioglitazone is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.

Metformin/pioglitazone may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Metformin/pioglitazone is used to improve blood sugar control in adults with type 2 diabetes. It’s used along with diet and exercise.

 Metformin/pioglitazone isn’t used to treat type 1 diabetes. Also, it isn’t used to treat diabetic ketoacidosis, a complication of diabetes that occurs when your body produces high levels of blood acids called ketones.

How it works

Metformin/pioglitazone is a combination of two diabetes medications that work in different ways.

A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Metformin belongs to a class of drugs called biguanides.

Metformin reduces the amount of glucose (sugar) made by your liver, lowers the amount of glucose your body absorbs, and increases the effect of insulin on your body. Insulin is a hormone that helps your body remove extra sugar from your blood. This lowers your blood sugar levels.

Pioglitazone belongs to a class of drugs called thiazolidinediones. It works by helping you respond better to the insulin that your body makes. It helps insulin take the glucose from your bloodstream and move it into the cells, where it’s used to make fuel or energy. This lowers your blood sugar levels.

Mechanism of Action of Pioglitazone 30mg:

Pioglitazone Is As A Potent And Highly Selective Agonist For The Peroxisome Proliferator Activated Receptor-Γ (PPARγ). Activation Of These Receptors Promotes The Production Of Gene Products Involved In Lipid And Glucose Metabolism. It Also Improves Insulin Response To Target Cells W/O Increasing The Pancreatic Secretion Of Insulin. Onset: Delayed. Absorption: Rapidly Absorbed. Bioavailability: >80%. Time To Peak Plasma Concentration: Approx 2 Hr. Distribution: Volume Of Distribution: 0.63 L/Kg. Plasma Protein Binding: >99% (Mainly To Albumin). Metabolism: Extensive Hepatic Metabolism Via CYP2C8 And CYP3A4 Isoenzymes To Its Active And Inactive Metabolites. Excretion: Via Urine (15-30%); Faeces (As Metabolites). Elimination Half-Life: 3-7 Hr (Parent Drug).

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Low blood sugar (hypoglycemia) Symptoms can include:

  • mood changes, such as irritability, anger, or sadness
  • confusion
  • lightheadedness
  • dizziness
  • sleepiness
  • blurred vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness
  • tiredness
  • lack of coordination

Special Precautions for Pioglitazone 30mg:

Symptomatic And Congestive Heart Failure (NYHA Class I Or II). Mild Hepatic Impairment. Pregnancy And Lactation. Monitoring Parameters Monitor For Signs And Symptoms Of Heart Failure (E.G. Dyspnoea, Rapid Wt. Gain, Unexplained Fatigue Or Cough), Bladder Cancer (E.G. Blood In Urine, Urinary Urgency, Pain On Urination, Or Back Or Abdominal Pain), And Fluid Retention. Periodically Monitor Fasting Plasma Glucose Levels. LFT Should Be Performed Prior To Treatment And Monitor Periodically. Patient Counselling Adequate Contraception Is Recommended In Premenopausal Anovulatory Women As Pioglitazone May Cause Resumption Of Ovulation.

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