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Phentermine And Topiramate Extended Release Capsules

phentermine and topiramate extended release capsules


Obesity is a rapidly growing medical condition in the U.S. In 2010, approximately 35% of American adults were classified as obese.1 The high prevalence of obesity has affected health care expenditures, with more than $99 billion spent in 1999, attributed to complications of the disease.1 Obesity is associated with a higher incidence of and higher morbidity rates of several disease states (Table 1); it also has adverse effects on women’s health, including complications during pregnancy and menstrual irregularities. Colon, breast, and endometrial cancer are found at higher incidence rates in obese patients, and overall mortality rates are increased by 50% to 100%.2

What is this medicine?

Phentermine; topiramate (FEN ter meen; toe PYRE a mate) is a combination of two medicines used with a reduced calorie diet and exercise to help you lose weight.

This medicine is only available through certified pharmacies enrolled in a special program. Your healthcare professional will tell you where you can get your medicine. If you have additional questions, you can visit the manufacture's website at or contact them by phone at 1-888-998-4887.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush or chew. This medicine is usually taken with or without food once per day in the morning. Avoid taking this medicine in the evening. It may interfere with sleep. Take your doses at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  •  Agitation
  • Diarrhea
  • Depression or other mental illness
  • Diabetes
  • Glaucoma
  • Heart disease
  • High or low blood pressure
  • History of anorexia or other eating disorder
  • History of substance abuse
  • Kidney stones or kidney disease
  • Liver disease
  • Lung disease like asthma, obstructive pulmonary disease, emphysema
  • Metabolic acidosis
  • On a ketogenic diet
  • Scheduled for surgery or a procedure
  • Suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
  • Taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • Thyroid disease
  • An unusual or allergic reaction to phentermine, topiramate, other medicines, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  •  Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • Blood in the urine
  • Changes in vision
  • Chest pain or chest tightness
  • Confusion
  • Depressed mood
  • Difficulty breathing
  • Dizziness
  • Fast or irregular heartbeat
  • Feeling anxious
  • Irritable
  • Loss of appetite
  • Low blood pressure
  • Pain in the lower back or side
  • Pain, tingling, numbness in the hands or feet
  • Pain when urinating
  • Palpitations
  • Redness, blistering, peeling or loosening of the skin, including inside the mouth
  • Shortness of breath
  • Suicidal thoughts or other mood changes
  • Trouble passing urine or change in the amount of urine
  • Trouble walking, dizziness, loss of balance or coordination
  • Unusually weak or tired

 Missed Dose

If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

 Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised March 2018. Copyright(c) 2018 First Databank, Inc.

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