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Pazopanib Side Effects

pazopanib side effects

What Is Pazopanib?

Pazopanib is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer). Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma. Pazopanib may also be used for purposes not listed in this medication guide.

Pazopanib Interactions

Grapefruit and grapefruit juice may interact with pazopanib and lead to unwanted side effects. Avoid the use of grapefruit products while taking pazopanib. Ask your doctor before using an antacid, and use only the type your doctor recommends. Do not take an antacid within several hours before or after you have taken your pazopanib dose. Avoid taking stomach acid reducers (Axid, Nexium, Pepcid, Prevacid, Prilosec, Protonix, Tagamet, Zantac, Zegerid) while taking pazopanib.

Pazopanib shows better quality-of-life in advanced kidney cancer

Two oral targeted drugs approved for metastatic kidney cancer worked equally well, but one proved superior in tolerability, according to results of a large international clinical trial led by researchers at Dana-Farber Cancer Institute.

Pazopanib (Votrient) and sunitinib (Sutent), both recently approved as first-line treatments for advanced renal cell cancer, had similar benefits in delaying progression of the disease, but the safety profile and many measures of quality of life favored pazopanib, suggesting a potential shift in standard of care in metastatic kidney cancer.

pazopanib Side Effects

Votrient (pazopanib) is a tyrosine kinase inhibitor used to treat kidney cancer, and it may also be used to treat certain other types of cancer (soft tissue sarcoma). Common side effects of Votrient include:

  • headache,
  • loss of appetite,
  • weight loss,
  • altered sense of taste,
  • nausea and vomiting (may be severe),
  • diarrhea,
  • numbness/tingling/redness in hands/feet,
  • changes in hair or skin color,
  • joint or muscle pain,
  • feeling tired/weak,
  • fatigue,
  • high blood pressure (hypertension),
  • tumor pain,
  • stomach or abdominal pain,
  • shortness of breath,
  • peeling rash,
  • cough,
  • swelling of extremities,

Many people have more frequent/loose stools or diarrhea while taking Votrient. Diarrhea can cause a serious loss of body water (dehydration). Tell your doctor if you develop signs of dehydration (such as extreme thirst, decreased urination, muscle cramps, weakness, or fainting). Votrient may cause high blood pressure. Temporary hair loss and/or change in hair or skin color may occur. Normal hair growth should return after treatment with Votrient has ended.

Votrient Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. unusual bleeding or bruising; slow healing of a wound or surgical incision, or any wound that will not heal; sudden chest pain or discomfort, wheezing, dry cough; headache, confusion, change in mental status, vision loss, seizure (convulsions); signs of a stroke or blood clot--sudden numbness or weakness, severe headache, slurred speech, vision problems, chest pain, sudden shortness of breath, pain or cold feeling in an arm or leg;

heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; signs of other heart problems--feeling short of breath (even with mild exertion), swelling or rapid weight gain, headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats.

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