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Neostigmine Bromide

Neostigmine Bromide

Uses

Neostigmine is used to improve muscle strength in patients with a certain muscle disease (myasthenia gravis). It works by preventing the breakdown of a certain natural substance (acetylcholine) in your body. Acetylcholine is needed for normal muscle function.

How to use Neostigmine Bromide Tablet

Take this medication by mouth with or without food as directed by your doctor. Taking this medication with food or milk may help to decrease side effects.

Dosage is based on your medical condition and response to therapy. Talk with your doctor about how you respond to the medication and about when you feel the most tired or weak so that your doctor can make the proper dosage changes.

Do not increase your dose or take this medication more often than prescribed. Doing so may increase the risk of serious side effects.

Tell your doctor if your condition persists or worsens or if the medication stops working well.

Side effects

Neostigmine can induce generic ocular side effects including: headache, brow pain, blurred vision, phacodonesis, pericorneal injection, congestive iritis, various allergic reactions, and rarely, retinal detachment.[10]

Neostigmine will cause slowing of the heart rate (bradycardia); for this reason it is usually given along with a parasympatholytic drug such as atropine or glycopyrrolate.

Gastrointestinal symptoms occur earliest after ingestion and include anorexia, nausea, vomiting, abdominal cramps, and diarrhea.[11]

Special warnings and precautions for use

  • Extreme caution is required when administering Neostigmine Bromide to patients with bronchial asthma.
  • Care should also be taken in patients with bradycardia, recent coronary occlusion, hypotension, peptic ulcer, vagotonia, epilepsy or parkinsonism.
  • Usual Adult Dose for Urinary Retention
  • Prevention of Postoperative Distention:
  • Initial dose: 0.25 mg subcutaneously or intramuscularly as soon as possible after operation
  • Duration of therapy: Repeat every 4 to 6 hours for 2 to 3 days.
  • Treatment of Postoperative Distention: 1 mL of 1:2000 solution (0.5 mg) subcutaneously or intramuscularly
  • Prevention of Urinary Retention:
  • Initial dose: 0.25 mg subcutaneously or intramuscularly as soon as possible after operation
  • Duration of therapy: Repeat every 4 to 6 hours for 2 to 3 days
  • Treatment of Urinary Retention:
  • Initial: 1 mL of 1:2000 solution (0.5 mg) subcutaneously or intramuscularly
  • Duration of therapy: After patient has voided continue 0.5 mg subcutaneously or intramuscularly every 3 hours for at least 5 injection

CONDITIONS OF USE:

The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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