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Naproxen Overdose

naproxen overdose

What is naproxen?

There are two types of prescription naproxen: regular naproxen and naproxen sodium. Regular naproxen comes as an oral immediate-release tablet, an oral delayed-release tablet, and an oral suspension. Naproxen sodium comes as an oral immediate-release tablet and an oral extended-release tablet.

Naproxen is also available in over-the-counter forms. This article only addresses prescription forms of naproxen.

Naproxen Drug Class

Naproxen is part of the drug class:

Antiinflammatory preparations, non steroids for topical use

Side Effects of Naproxen

Serious side effects have been reported with naproxen.  See "Drug Precautions" section.

Common side effects of naproxen include:

  • heartburn
  • stomach pain
  • nausea
  • constipation
  • headache
  • dizziness
  • swelling of arms or legs
  • rash
  • Heartburn
  • Stomach ache
  • Constipation
  • Headache
  • Dizziness
  • Drowsiness
  • Itching
  • Skin rash
  • Skin bruising
  • Ringing in the ears
  • Fluid retention


Naproxen comes as a regular tablet, an enteric coated tablet (delayed-release tablet), an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The extended-release tablets are usually taken once a day. The tablets, enteric coated tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking naproxen on a regular basis, you should take it at the same time(s) every day.

Naproxen Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.  Especially tell your doctor if you take:

  • angiotensin receptor blockers (ARBs) such as losartan (Cozaar), irbesartan (Avapro), olmesartan (Benicar), candesartan (Atacand), and valsartan (Diovan)
  • beta-blockers such as propranolol (Inderal), timolol (Timoptic), atenolol (Tenormin), and metoprolol (Lopressor, Toprol)
  • antacids such as Tums, Citrical, or Rolaids
  • sucralfate (Carafate)
  • aspirin (Ecotrin)
  • diuretics such as furosemide (Lasix), hydrochlorothiazide (Microzide), and chlorthalidone (Thalitone)
  • cholestyramine (Questran)
  • lithium
  • methotrexate (Trexall)
  • warfarin (Coumadin, Jantoven)
  • selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro)

Naproxen sodium overdose

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Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate aches and pains. Naproxen sodium overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of this medicine.

This is for information only and not for use in the treatment or management of an actual overdose. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

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