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Naproxen For Migraine

naproxen for migraine


Naproxen is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

Prescription drugs or over-the-counter, what’s the difference?

Prescription drugs are those that can’t be bought without a written doctor’s prescription. These drugs need a doctor’s supervision to properly diagnose the condition and properly use the drug. Over-the-counter drugs treat conditions that the average person is likely to correctly diagnose. These nonprescription medications also contain instructions that are simple to follow.

several over-the-counter migraine medicines, some that treat migraine in general and others that treat specific types of migraine such as over-the-counter drugs for menstrual migraine.

Some examples include:

  • Aspirin
  • Ibuprofen (NSAIDs), sold under the brand names Motrin and Advil
  • Naproxen (NSAIDs), sold under the brand name Aleve
  • Acetaminophen, sold under the brand name Tylenol
  • Acetaminophen plus caffeine, APAP and Aspirin, sold under the brand name Excedrin Migraine


Cardiovascular Thrombotic Events: NSAIDs cause an increased risk of serious cardiovascular thrombotic events including myocardial infarction, and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. This drug is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

-Gastrointestinal (GI) Risk: NSAIDs cause an increased risk of serious GI adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Treximet Side Effects

  • dizziness
  • drowsiness
  • flushing (warmth, heat, or tingly feeling)
  • redness in your face
  • feelings of prickling/heat
  • tiredness
  • nausea
  • heartburn
  • constipation
  • upset stomach
  • dry mouth
  • tight muscles
  • weakness

Naproxen / Sumatriptan Dosage

Maximum dose: 2 tablets (sumatriptan-naproxen 85/500 mg) in a 24-hour period taken at least 2 hours apart

Use only if a clear diagnosis of migraine has been established; if migraine does not respond to treatment, reconsider the diagnosis of migraine before treating any subsequent attacks.

The safety of treating more than 5 migraines headaches (on average) in a 30-day period has not been established.


Before taking naproxen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), blood disorders (such as anemia), bleeding/clotting problems, growths in the nose (nasal polyps), heart disease (such as previous heart attack), high blood pressure, liver disease, stroke, swelling (edema, fluid retention), stomach/intestinal/esophagus problems (such as bleeding, heartburn, ulcers).

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