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Naproxen And Tylenol

naproxen and tylenol


Acetaminophen and naproxen work in different ways to control pain and have few overlapping side effects. For most people, it’s okay to use them together. However, it’s important to understand how each drug works differently to control your pain. Here are some tips to help you take these drugs together safely, plus warnings and other information you should know.

How they work

Both naproxen and acetaminophen help reduce fever and relieve mild to moderate pain. Examples of these types of pain include:

  • sore throats
  • headaches
  • body or muscle aches
  • menstrual cramps
  • arthritis
  • toothaches

How does Aleve work?

Aleve is an anti-inflammatory drug. As inflammation decreases, a person usually experiences less pain.

Naproxen sodium is the active ingredient in Aleve. Naproxen sodium belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs).

NSAIDs reduce the chemicals that cause inflammation.

General rules

It’s a good idea to start taking only one type of pain relief medication at a time. You can take one drug and see how it works before you add a second.

Acetaminophen, depending on the strength and type, can be taken as often as every four to six hours. Naproxen, depending on the strength and type, can be taken as often as every eight to 12 hours. Products marked “extra strength” or “all-day relief” should not be taken as often.

You don’t have to adjust your doses of either drug or take them at different times if you take both drugs. That said, taking the medications alternately may help provide better pain relief. For example, if you take a dose of naproxen, you can’t take another dose for eight hours. Five hours in, though, your pain may start bothering you again. In cases like this, you could take some acetaminophen to tide you over until your next dose of naproxen.


The biggest consideration when taking acetaminophen is the possibility of overdose. Acetaminophen is a common ingredient in many different over-the-counter products, so it can be easy to take too much without even realizing it.

An acetaminophen overdose can cause serious liver damage. To avoid this, you should understand your limit for acetaminophen. Generally, people shouldn't have more than 3 g of acetaminophen per day. You can talk to your doctor to find out the specific limit that’s right for you. Then, keep track of how much acetaminophen you take by reading all medication labels. It’s often best to use only one medication that contains acetaminophen at a time.


Naproxen and acetaminophen don’t interact with each other. However, they both may interact with other medications such as warfarin. If you take warfarin or another type of blood thinner, be sure to check with your doctor or pharmacist before you use either acetaminophen or naproxen.

How does Tylenol work?

The active ingredient in Tylenol is acetaminophen, which blocks pain signals in the brain.

Acetaminophen is an analgesic and antipyretic. It inhibits the pain sensors in the nervous system, and it can also reduce fevers.

However, researchers still do not fully understand how acetaminophen blocks pain signals.


Aleve and tylenol dosage

Doctors recommend starting off with the smallest dose of a drug, as this reduces the risk of side effects.

Healthcare professionals usually suggest starting off with the smallest dosage of a drug. If the symptoms persist, they then recommend increasing the dosage or adding another medication.

Starting off with the lowest effective dosage reduces the risk of side effects.

Doctors generally recommend taking different dosages of Aleve and Tylenol. The same is true for other drugs that contain naproxen or

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